Wei Zeng, Chi Han, Sarah Mohammed, Shanshan Li, Yixuan Song, Fengxia Sun and Yunfei Du
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引用次数: 0
摘要
吲哚是一种著名的杂环骨架,广泛存在于天然化合物和具有生物活性的化合物中。框架中含有吲哚骨架的药物具有广泛的药理特性,包括抗病毒、抗肿瘤、镇痛和其他治疗活性,许多含吲哚的药物已被证实具有良好的药代动力学和药理作用。在过去的几十年中,美国 FDA 批准了 40 多种含吲哚药物用于治疗各种临床疾病,吲哚相关药物的开发引起了药物化学家的极大关注。本综述旨在概述所有已批准的含吲哚核药物,重点介绍其靶点、药理活性和 SAR 研究。
Indole-containing pharmaceuticals: targets, pharmacological activities, and SAR studies
Indole is a prestigious heterocyclic skeleton widely found in both naturally-occurring and biologically-active compounds. Pharmaceutical agents containing an indole skeleton in their framework possess a wide range of pharmacological properties, including antiviral, antitumor, analgesic, and other therapeutic activities, and many indole-containing drugs have been proven to have excellent pharmacokinetic and pharmacological effects. Over the past few decades, the FDA has approved over 40 indole-containing drugs for the treatment of various clinical conditions, and the development of indole-related drugs has attracted significant attention from medicinal chemists. This review aims to provide an overview of all the approved drugs that contain an indole nucleus, focusing on their targets, pharmacological activities, and SAR studies.
期刊介绍:
Research and review articles in medicinal chemistry and related drug discovery science; the official journal of the European Federation for Medicinal Chemistry.
In 2020, MedChemComm will change its name to RSC Medicinal Chemistry. Issue 12, 2019 will be the last issue as MedChemComm.