神经系统疾病与妇女健康：分子神经影像技术的贡献。

IF 4.6 2区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Seminars in nuclear medicine Pub Date : 2024-03-01 DOI:10.1053/j.semnuclmed.2024.01.010

Ozgul Ekmekcioglu MD , Nathalie L. Albert MD , Kathrin Heinrich MD , Nelleke Tolboom MD , Donatienne Van Weehaeghe MD, PhD , Tatiana Traub-Weidinger MD , Lutfiye Ozlem Atay MD , Valentina Garibotto MD , Silvia Morbelli MD

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引用次数: 0

摘要

大脑生理和药物作用机制的性别差异已被广泛报道。这些生物差异，从结构到激素和遗传方面，都会对健康功能和疾病机制产生深远影响，并可能对治疗和药物开发产生影响。分子神经影像学技术可能有助于揭示性别对大脑功能的影响，以及多种疾病的神经病理学变化。这篇叙述性综述总结了基于正电子发射计算机断层显像和 SPECT 成像的最新证据，突出强调了正常情况下和各种神经系统疾病中的性别差异。

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Neurological Disorders and Women's Health: Contribution of Molecular Neuroimaging Techniques

Sex differences in brain physiology and the mechanisms of drug action have been extensively reported. These biological variances, from structure to hormonal and genetic aspects, can profoundly influence healthy functioning and disease mechanisms and might have implications for treatment and drug development. Molecular neuroimaging techniques may help to disclose sex's impact on brain functioning, as well as the neuropathological changes underpinning several diseases. This narrative review summarizes recent lines of evidence based on PET and SPECT imaging, highlighting sex differences in normal conditions and various neurological disorders.

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来源期刊

Seminars in nuclear medicine 医学-核医学

CiteScore

9.80

自引率

6.10%

发文量

审稿时长

14 days

期刊介绍： Seminars in Nuclear Medicine is the leading review journal in nuclear medicine. Each issue brings you expert reviews and commentary on a single topic as selected by the Editors. The journal contains extensive coverage of the field of nuclear medicine, including PET, SPECT, and other molecular imaging studies, and related imaging studies. Full-color illustrations are used throughout to highlight important findings. Seminars is included in PubMed/Medline, Thomson/ISI, and other major scientific indexes.