Felipe Alves Machado, Gustavo J Almeida, André Luiz Maia do Vale, Alexandre Lima de Araújo Ribeiro, Graziella França Bernardelli Cipriano, Gerson Cipriano Junior, Wagner Rodrigues Martins
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Several systematic reviews have reported inconclusive results due to discrepancies in study findings, heterogeneity of results, evaluated time points, and research questions explored.</p><p><strong>Objective: </strong>To perform an overview of systematic reviews with meta-analyses, synthesizing the most recent evidence on the effects of muscle strength training with BFR for knee OA.</p><p><strong>Methodology: </strong>Systematic reviews that include primary controlled and randomized clinical trials will be considered for inclusion. Articles will be considered only if they present a clear and reproducible methodological structure, and when they clearly demonstrate that a critical analysis of the evidence was carried out using instrumented analysis. Narrative reviews, other types of review, overviews of systematic reviews, and diagnostic, prognostic and economic evaluation studies will be excluded. Studies must include adults aged 40 years and older with a diagnosis of knee OA. 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引用次数: 0
摘要
背景：骨关节炎（OA）是与人口老龄化相关的最常见、最普遍的肌肉骨骼疾病，对人体功能和生活质量造成负面影响。膝关节 OA 的后果之一是股四头肌无力。在不能耐受高负荷运动的情况下，使用低负荷运动和血流限制（BFR）进行肌肉骨骼康复训练可能是替代高负荷运动的有效方法。由于研究结果的差异、结果的异质性、评估的时间点和探讨的研究问题，一些系统综述报告了不确定的结果：综述具有荟萃分析的系统性综述，归纳有关使用BFR进行肌力训练治疗膝关节OA效果的最新证据：将考虑纳入包含主要对照和随机临床试验的系统综述。文章必须具有清晰且可重复的方法结构，并清楚地表明已使用工具分析法对证据进行了批判性分析，才会被考虑纳入。叙述性综述、其他类型的综述、系统性综述概述以及诊断、预后和经济评估研究将被排除在外。研究必须包括 40 岁及以上确诊为膝关节 OA 的成年人。两位作者将在一位经验丰富的图书管理员的指导下进行电子检索。将检索以下数据库：PubMed（通过 MEDLINE）、Embase（通过 Embase）、CENTRAL（通过 Cochrane Central Register of Controlled Trials）、PEDro（通过 PEDro）、Cumulative Index to Nursing and Allied Health Literature（通过 EBSCO host）、Web of Science（通过 Web of Science）和灰色文献。数据库中使用的检索策略将遵循缩写 PICOS（人群、干预、比较、结果和研究设计）。将使用 Rayyan (http://rayyan.qcri.org) 对检索策略确定的研究进行筛选（即标题和摘要）。质量评估将使用 "多重系统综述评估"（AMSTAR-2）工具进行：prospero，CRD42022367209。
Effects of blood flow restriction therapy in patients with knee osteoarthritis: protocol for an overview of systematic reviews.
Background: Osteoarthritis (OA) is the most common and prevalent musculoskeletal disease associated with population aging, negatively impacting function and quality of life. A consequence of knee OA is quadriceps muscle weakness. Musculoskeletal rehabilitation using low load exercises, associated with Blood Flow Restriction (BFR) may be a useful alternative to high load exercises when those cannot be tolerated. Several systematic reviews have reported inconclusive results due to discrepancies in study findings, heterogeneity of results, evaluated time points, and research questions explored.
Objective: To perform an overview of systematic reviews with meta-analyses, synthesizing the most recent evidence on the effects of muscle strength training with BFR for knee OA.
Methodology: Systematic reviews that include primary controlled and randomized clinical trials will be considered for inclusion. Articles will be considered only if they present a clear and reproducible methodological structure, and when they clearly demonstrate that a critical analysis of the evidence was carried out using instrumented analysis. Narrative reviews, other types of review, overviews of systematic reviews, and diagnostic, prognostic and economic evaluation studies will be excluded. Studies must include adults aged 40 years and older with a diagnosis of knee OA. Two authors will perform an electronic search with guidance from an experienced librarian. The following databases will be searched: PubMed via MEDLINE, Embase, CENTRAL (Cochrane Central Register of Controlled Trials), PEDro, Cumulative Index to Nursing and Allied Health Literature (CINAHL) via EBSCO host, Web of Science, and the gray literature. The search strategy used in the databases will follow the acronym PICOS (population, intervention, comparison, outcome, and study design). Screening (i.e., titles and abstracts) of studies identified by the search strategy will be selected using Rayyan (http://rayyan.qcri.org). The quality assessment will be performed using the "Assessment of Multiple Systematic Reviews" (AMSTAR-2) tool.
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