作为肺癌生物学调控网络的 circRNA/miRNA/mRNA 相互作用的功能意义。

IF 3.4 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Shengnan Jia , Ling Yu , Lihui Wang , Liping Peng
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引用次数: 0

摘要

肺癌是癌症相关死亡的主要原因,由于预后不良,给患者带来了巨大的挑战。最近的研究越来越多地发现环状 RNA 与肺癌的发生和发展有关。研究发现,这些环状 RNA 会影响肿瘤行为的各个方面,包括增殖、转移、细胞周期调节、细胞凋亡、癌症干细胞、治疗反应和肿瘤微环境。环状 RNA 发挥影响的关键机制之一是其作为 miRNA 海绵的能力,即封存 microRNA 并阻止它们靶向其他 RNA 分子。越来越多的证据表明,环状 RNA 可作为竞争性内源性 RNA 发挥作用,通过封存 microRNA 影响靶 mRNA 的表达。涉及环状 RNA、microRNA 和 mRNA 的竞争性内源性 RNA 网络的失调会导致肺癌发病机制中的癌基因和肿瘤抑制因子的异常表达。了解环状 RNA、microRNA 和 mRNA 之间的动态相互作用和分子机制,对促进肺癌的早期诊断、个性化治疗干预和改善患者预后大有希望。因此,本研究旨在深入探讨环状 RNA/microRNA/mRNAs 相互作用在肺癌发病机制中的执行作用,以及它们在诊断肺癌、预测患者预后和指导靶向治疗中的潜在作用。通过全面概述作为肺癌驱动因素的轴的失调,我们旨在为将来将其转化为临床实践铺平道路。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The functional significance of circRNA/miRNA/mRNA interactions as a regulatory network in lung cancer biology

Lung cancer, the leading cause of cancer-related deaths, presents significant challenges to patients due to its poor prognosis. Recent research has increasingly implicated circular RNAs in the development and progression of lung cancer. These circular RNAs have been found to impact various aspects of tumor behavior, including proliferation, metastasis, cell cycle regulation, apoptosis, cancer stem cells, therapy response, and the tumor microenvironment. One of the key mechanisms by which circular RNAs exert their influence is through their ability to act as miRNA sponges, sequestering microRNAs and preventing them from targeting other RNA molecules. Accumulating evidence suggests that circular RNAs can function as competing endogenous RNAs, affecting the expression of target mRNAs by sequestering microRNAs. Dysregulation of competing endogenous RNAs networks involving circular RNAs, microRNAs, and mRNAs leads to the aberrant expression of oncogenes and tumor suppressors involved in lung cancer pathogenesis. Understanding the dynamic interplay and molecular mechanisms among circular RNAs, microRNAs, and mRNAs holds great promise for advancing early diagnosis, personalized therapeutic interventions, and improved patient outcomes in lung cancer. Therefore, this study aims to provide an in-depth exploration of the executive roles of circular RNAs/microRNAs/ mRNAs interactions in lung cancer pathogenesis and their potential utility for diagnosing lung cancer, predicting patient prognosis, and guiding targeted therapies. By offering a comprehensive overview of the dysregulation of the axes as driving factors in lung cancer, we aim to pave the way for their translation into clinical practice in the future.

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来源期刊
CiteScore
8.10
自引率
0.00%
发文量
124
审稿时长
19 days
期刊介绍: IJBCB publishes original research articles, invited reviews and in-focus articles in all areas of cell and molecular biology and biomedical research. Topics of interest include, but are not limited to: -Mechanistic studies of cells, cell organelles, sub-cellular molecular pathways and metabolism -Novel insights into disease pathogenesis -Nanotechnology with implication to biological and medical processes -Genomics and bioinformatics
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