在了解潜伏结核感染的免疫稳态方面取得的进展。

IF 4.6 3区 医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL
WIREs Mechanisms of Disease Pub Date : 2024-07-01 Epub Date: 2024-02-13 DOI:10.1002/wsbm.1643
Liangfei Niu, Hao Wang, Geyang Luo, Jing Zhou, Zhidong Hu, Bo Yan
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引用次数: 0

摘要

全球近四分之一的人口感染了结核分枝杆菌(Mtb),约 90%-95% 的人无症状,处于结核病潜伏感染(LTBI)状态,估计有 5%-10% 的潜伏感染者最终会发展为活动性结核病(ATB)。虽然人们普遍认为,LTBI 向 ATB 的转变是宿主免疫平衡被破坏和保护性免疫反应减弱的结果,但促进这种转变的确切潜在免疫机制还没有得到很好的描述。因此,很难提前准确预测肺结核(TB)的进展情况,这就使得LTBI人群成为肺结核防控的重大威胁。本文从三个方面系统地探讨了LTBI的免疫调节机制和转化研究:(1)LTBI和ATB不同的免疫细胞学特征;(2)与宿主抗结核免疫和代谢途径相关的LTBI诊断标记物的发现;(3)LTBI疫苗的研发重点。本文归类于传染病 > 分子和细胞生理学 传染病 > 遗传学/基因组学/表观遗传学 免疫系统疾病 > 遗传学/基因组学/表观遗传学。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Advances in understanding immune homeostasis in latent tuberculosis infection.

Nearly one-fourth of the global population is infected by Mycobacterium tuberculosis (Mtb), and approximately 90%-95% remain asymptomatic as latent tuberculosis infection (LTBI), an estimated 5%-10% of those with latent infections will eventually progress to active tuberculosis (ATB). Although it is widely accepted that LTBI transitioning to ATB results from a disruption of host immune balance and a weakening of protective immune responses, the exact underlying immunological mechanisms that promote this conversion are not well characterized. Thus, it is difficult to accurately predict tuberculosis (TB) progression in advance, leaving the LTBI population as a significant threat to TB prevention and control. This article systematically explores three aspects related to the immunoregulatory mechanisms and translational research about LTBI: (1) the distinct immunocytological characteristics of LTBI and ATB, (2) LTBI diagnostic markers discovery related to host anti-TB immunity and metabolic pathways, and (3) vaccine development focus on LTBI. This article is categorized under: Infectious Diseases > Molecular and Cellular Physiology Infectious Diseases > Genetics/Genomics/Epigenetics Immune System Diseases > Genetics/Genomics/Epigenetics.

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来源期刊
WIREs Mechanisms of Disease
WIREs Mechanisms of Disease MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
11.40
自引率
0.00%
发文量
45
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