Yu Li, Haiting Huang, Cuijin Gu, Wenyi Huang, Xianxian Chen, Xiaoting Lu, Aijia You, Sen Ye, Jun Zhong, Yao Zhao, Yu Yan, Chun Li
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引用次数: 0
摘要
褥疮(PU)是一个难以解决的世界性难题,因为相关的炎症反应、局部缺氧和反复缺血/再灌注,给患者造成了巨大的痛苦和经济负担。传统中药龟板散可治疗皮肤创伤,但其成分复杂,使用不便。在此,我们将胆固醇肉豆蔻酸酯(S8)与具有消炎抗菌作用的小檗碱(BBR)作为药物,以羟丙基甲基纤维素和聚乙烯吡咯烷酮 K30 为载体,构建了一种新型成膜聚合物溶液(S8 + BBR FFPS),全面研究了其对 PU 的修复作用,并在大鼠 PU 模型中探索了其潜在机制。结果表明,S8 + BBR FFPS 在 PU 愈合过程中可抑制过度炎症反应,促进上皮重建,促进毛囊生长,这可能与 S8 + BBR FFPS 激活 Wnt/β-catenin 信号通路,介导毛囊干细胞增殖,维持皮肤稳态有关。因此,S8 + BBR FFPS 可能是治疗慢性皮肤损伤的潜在候选药物,它与 Wnt/β-catenin 信号通路的关联可能为指导设计用于慢性伤口修复的生物材料伤口敷料提供了新思路。
Film-forming polymer solutions containing cholesterol myristate and berberine mediate pressure ulcer repair via the Wnt/β-catenin pathway.
Pressure ulcer (PU) is a worldwide problem that is difficult to address because of the related inflammatory response, local hypoxia, and repeated ischaemia/reperfusion, causing great suffering and financial burden to patients. Traditional Chinese medicine turtle plate powder can treat skin trauma, but its composition is complex and inconvenient to use. Here, we combined cholesterol myristate (S8) with berberine (BBR), with anti-inflammatory and antibacterial effects, as a drug and used hydroxypropyl methylcellulose and polyvinylpyrrolidone K30 as carriers to construct a novel film-forming polymeric solution (S8 + BBR FFPS), comprehensively study its reparative effect on PU and explore the potential mechanism in rat PU models. The results showed that S8 + BBR FFPS inhibits excessive inflammatory response, promotes re-epithelialization, and promotes hair follicle growth during the healing process of PU, which may be related to the activation of the Wnt/β-catenin signalling pathway by S8 + BBR FFPS to mediate hair follicle stem cell proliferation and maintain skin homeostasis. Therefore, S8 + BBR FFPS may be a potential candidate for the treatment of chronic skin injury, and its association with the Wnt/β-catenin signalling pathway may provide new ideas to guide the design of biomaterial-based wound dressings for chronic wound repair.
期刊介绍:
Wound Repair and Regeneration provides extensive international coverage of cellular and molecular biology, connective tissue, and biological mediator studies in the field of tissue repair and regeneration and serves a diverse audience of surgeons, plastic surgeons, dermatologists, biochemists, cell biologists, and others.
Wound Repair and Regeneration is the official journal of The Wound Healing Society, The European Tissue Repair Society, The Japanese Society for Wound Healing, and The Australian Wound Management Association.