Joshua S Suppree, Siddarth Kannan, David M Hughes, Michael D Jenkinson, Rasheed Zakaria
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引用次数: 0
摘要
脑转移瘤是一项日益严峻的医疗挑战,其发病率的上升归因于早期发现和系统性癌症治疗方法的改进。我们进行了一项系统性回顾和荟萃分析,以研究在不进行辅助治疗的情况下,手术切除脑转移瘤后的局部复发率。分析包括四项研究,共 235 个病例。结果发现,12 个月后的局部复发率为 48.1%(95% CI 41.2-58.9)。这些研究结果表明,手术后12个月内出现局部复发的患者比例很高,强调在放弃辅助放疗而选择具有潜在但未经证实的中枢神经系统穿透性的全身治疗时,需要进行警惕性监测。该分析凸显了这一患者群体尚未得到满足的需求。
Letter: Estimating the baseline local recurrence rate for a brain metastasis after neurosurgical resection.
Brain metastases represent a growing healthcare challenge with a rising incidence attributed to earlier detection and improved systemic cancer treatments. We conducted a systematic review and meta-analysis to investigate the local recurrence rate following surgical resection of a brain metastasis without adjuvant therapy. The analysis included four studies with a total of 235 cases. It was found that the rate of local recurrence by 12-months was 48.1% (95% CI 41.2-58.9). These findings underscore the high rate of patients who will experience local recurrence within 12-months of surgery, emphasising the need for vigilant surveillance when omitting adjuvant radiotherapy in favour of systemic treatments with potential but unproven CNS penetrance. The analysis highlights unmet needs in this patient population.
期刊介绍:
The Journal''s scope encompasses all aspects of metastasis research, whether laboratory-based, experimental or clinical and therapeutic. It covers such areas as molecular biology, pharmacology, tumor biology, and clinical cancer treatment (with all its subdivisions of surgery, chemotherapy and radio-therapy as well as pathology and epidemiology) insofar as these disciplines are concerned with the Journal''s core subject of metastasis formation, prevention and treatment.