母乳中的补体可塑造婴儿的微生物群

IF 67.7 1区 医学 Q1 IMMUNOLOGY
Maria Papatriantafyllou
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引用次数: 0

摘要

众所周知,母乳中含有抗体和其他免疫介质,可提供免疫保护并塑造肠道微生物群。母乳中还含有补体蛋白,但其生理作用尚不清楚。Xu 等人的一项研究表明,小鼠母乳中的补体成分通过选择性地消除特定革兰氏阳性细菌种类,直接支持新生儿肠道中的 "保护性 "肠道微生物群。作者发现,补体缺乏的母鼠培育的幼鼠在受到天然小鼠肠道病原体柠檬杆菌(Citrobacter rodentium)的挑战时会出现肠道炎症、屏障损伤和致死率增加。对微生物群的进一步分析显示,鼠杆菌的致病性与肠道共生菌的组成有关,特别是与革兰氏阳性扁球菌 B3 的增加有关。研究发现,小鼠和人类母乳中的补体可通过 C1 启动机制直接裂解 S. lentus B3,该机制需要膜攻击复合物的形成,但与抗体无关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Complement in maternal milk shapes the infant microbiome
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来源期刊
Nature Reviews Immunology
Nature Reviews Immunology 医学-免疫学
CiteScore
93.40
自引率
0.40%
发文量
131
审稿时长
6-12 weeks
期刊介绍: Nature Reviews Immunology is a journal that provides comprehensive coverage of all areas of immunology, including fundamental mechanisms and applied aspects. It has two international standard serial numbers (ISSN): 1474-1733 for print and 1474-1741 for online. In addition to review articles, the journal also features recent developments and new primary papers in the field, as well as reflections on influential people, papers, and events in the development of immunology. The subjects covered by Nature Reviews Immunology include allergy and asthma, autoimmunity, antigen processing and presentation, apoptosis and cell death, chemokines and chemokine receptors, cytokines and cytokine receptors, development and function of cells of the immune system, haematopoiesis, infection and immunity, immunotherapy, innate immunity, mucosal immunology and the microbiota, regulation of the immune response, signalling in the immune system, transplantation, tumour immunology and immunotherapy, and vaccine development.
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