Michael Fleischer, Fabian Szepanowski, Anne K Mausberg, Livia Asan, Ellen Uslar, Denise Zwanziger, Lothar Volbracht, Mark Stettner, Christoph Kleinschnitz
{"title":"细胞因子（IL1β、IL6、TNFα）和血清皮质醇水平可能不是识别 COVID-19 急性后遗症患者的可靠生物标志物。","authors":"Michael Fleischer, Fabian Szepanowski, Anne K Mausberg, Livia Asan, Ellen Uslar, Denise Zwanziger, Lothar Volbracht, Mark Stettner, Christoph Kleinschnitz","doi":"10.1177/17562864241229567","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Post-acute sequelae of COVID-19 (PASC) comprise a broad spectrum of symptoms such as fatigue, general weakness, compromised attention and sleep or anxiety disorders. PASC represents a medical and socio-economic challenge.</p><p><strong>Objectives: </strong>Our study evaluated cytokines (IL-1β, IL-6 and TNFα) and cortisol levels in a cohort of typical patients with PASC, suffering concentration problems, fatigue and difficulties finding words.</p><p><strong>Design: </strong>This was a prospective cohort study. Four groups were analysed and compared: those who had never contracted SARS-CoV-2 (<i>n</i> = 13), infected but had no PASC (<i>n</i> = 34), infected with former PASC that resolved (<i>n</i> = 40) and patients with ongoing PASC after infection (<i>n</i> = 91).</p><p><strong>Methods: </strong>Cytokine and cortisol serum levels were determined in patients' blood samples.</p><p><strong>Results: </strong>Cytokine levels of IL-1β, IL-6, TNFα and cortisol levels did not differ between groups analysed.</p><p><strong>Conclusion: </strong>This may indicate a non-organic/psychosomatic genesis of PASC; further studies are needed to elucidate the underlying causes of PACS, and non-organic causes should not be overlooked.</p>","PeriodicalId":22980,"journal":{"name":"Therapeutic Advances in Neurological Disorders","volume":"17 ","pages":"17562864241229567"},"PeriodicalIF":4.7000,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10860378/pdf/","citationCount":"0","resultStr":"{\"title\":\"Cytokines (IL1β, IL6, TNFα) and serum cortisol levels may not constitute reliable biomarkers to identify individuals with post-acute sequelae of COVID-19.\",\"authors\":\"Michael Fleischer, Fabian Szepanowski, Anne K Mausberg, Livia Asan, Ellen Uslar, Denise Zwanziger, Lothar Volbracht, Mark Stettner, Christoph Kleinschnitz\",\"doi\":\"10.1177/17562864241229567\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Post-acute sequelae of COVID-19 (PASC) comprise a broad spectrum of symptoms such as fatigue, general weakness, compromised attention and sleep or anxiety disorders. PASC represents a medical and socio-economic challenge.</p><p><strong>Objectives: </strong>Our study evaluated cytokines (IL-1β, IL-6 and TNFα) and cortisol levels in a cohort of typical patients with PASC, suffering concentration problems, fatigue and difficulties finding words.</p><p><strong>Design: </strong>This was a prospective cohort study. Four groups were analysed and compared: those who had never contracted SARS-CoV-2 (<i>n</i> = 13), infected but had no PASC (<i>n</i> = 34), infected with former PASC that resolved (<i>n</i> = 40) and patients with ongoing PASC after infection (<i>n</i> = 91).</p><p><strong>Methods: </strong>Cytokine and cortisol serum levels were determined in patients' blood samples.</p><p><strong>Results: </strong>Cytokine levels of IL-1β, IL-6, TNFα and cortisol levels did not differ between groups analysed.</p><p><strong>Conclusion: </strong>This may indicate a non-organic/psychosomatic genesis of PASC; further studies are needed to elucidate the underlying causes of PACS, and non-organic causes should not be overlooked.</p>\",\"PeriodicalId\":22980,\"journal\":{\"name\":\"Therapeutic Advances in Neurological Disorders\",\"volume\":\"17 \",\"pages\":\"17562864241229567\"},\"PeriodicalIF\":4.7000,\"publicationDate\":\"2024-02-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10860378/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Therapeutic Advances in Neurological Disorders\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1177/17562864241229567\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q1\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Therapeutic Advances in Neurological Disorders","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/17562864241229567","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
Cytokines (IL1β, IL6, TNFα) and serum cortisol levels may not constitute reliable biomarkers to identify individuals with post-acute sequelae of COVID-19.
Background: Post-acute sequelae of COVID-19 (PASC) comprise a broad spectrum of symptoms such as fatigue, general weakness, compromised attention and sleep or anxiety disorders. PASC represents a medical and socio-economic challenge.
Objectives: Our study evaluated cytokines (IL-1β, IL-6 and TNFα) and cortisol levels in a cohort of typical patients with PASC, suffering concentration problems, fatigue and difficulties finding words.
Design: This was a prospective cohort study. Four groups were analysed and compared: those who had never contracted SARS-CoV-2 (n = 13), infected but had no PASC (n = 34), infected with former PASC that resolved (n = 40) and patients with ongoing PASC after infection (n = 91).
Methods: Cytokine and cortisol serum levels were determined in patients' blood samples.
Results: Cytokine levels of IL-1β, IL-6, TNFα and cortisol levels did not differ between groups analysed.
Conclusion: This may indicate a non-organic/psychosomatic genesis of PASC; further studies are needed to elucidate the underlying causes of PACS, and non-organic causes should not be overlooked.
期刊介绍：
Therapeutic Advances in Neurological Disorders is a peer-reviewed, open access journal delivering the highest quality articles, reviews, and scholarly comment on pioneering efforts and innovative studies across all areas of neurology. The journal has a strong clinical and pharmacological focus and is aimed at clinicians and researchers in neurology, providing a forum in print and online for publishing the highest quality articles in this area.
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