Michael Fleischer, Fabian Szepanowski, Anne K Mausberg, Livia Asan, Ellen Uslar, Denise Zwanziger, Lothar Volbracht, Mark Stettner, Christoph Kleinschnitz
{"title":"细胞因子（IL1β、IL6、TNFα）和血清皮质醇水平可能不是识别 COVID-19 急性后遗症患者的可靠生物标志物。","authors":"Michael Fleischer, Fabian Szepanowski, Anne K Mausberg, Livia Asan, Ellen Uslar, Denise Zwanziger, Lothar Volbracht, Mark Stettner, Christoph Kleinschnitz","doi":"10.1177/17562864241229567","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Post-acute sequelae of COVID-19 (PASC) comprise a broad spectrum of symptoms such as fatigue, general weakness, compromised attention and sleep or anxiety disorders. PASC represents a medical and socio-economic challenge.</p><p><strong>Objectives: </strong>Our study evaluated cytokines (IL-1β, IL-6 and TNFα) and cortisol levels in a cohort of typical patients with PASC, suffering concentration problems, fatigue and difficulties finding words.</p><p><strong>Design: </strong>This was a prospective cohort study. Four groups were analysed and compared: those who had never contracted SARS-CoV-2 (<i>n</i> = 13), infected but had no PASC (<i>n</i> = 34), infected with former PASC that resolved (<i>n</i> = 40) and patients with ongoing PASC after infection (<i>n</i> = 91).</p><p><strong>Methods: </strong>Cytokine and cortisol serum levels were determined in patients' blood samples.</p><p><strong>Results: </strong>Cytokine levels of IL-1β, IL-6, TNFα and cortisol levels did not differ between groups analysed.</p><p><strong>Conclusion: </strong>This may indicate a non-organic/psychosomatic genesis of PASC; further studies are needed to elucidate the underlying causes of PACS, and non-organic causes should not be overlooked.</p>","PeriodicalId":4,"journal":{"name":"ACS Applied Energy Materials","volume":"17 ","pages":"17562864241229567"},"PeriodicalIF":5.4000,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10860378/pdf/","citationCount":"0","resultStr":"{\"title\":\"Cytokines (IL1β, IL6, TNFα) and serum cortisol levels may not constitute reliable biomarkers to identify individuals with post-acute sequelae of COVID-19.\",\"authors\":\"Michael Fleischer, Fabian Szepanowski, Anne K Mausberg, Livia Asan, Ellen Uslar, Denise Zwanziger, Lothar Volbracht, Mark Stettner, Christoph Kleinschnitz\",\"doi\":\"10.1177/17562864241229567\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Post-acute sequelae of COVID-19 (PASC) comprise a broad spectrum of symptoms such as fatigue, general weakness, compromised attention and sleep or anxiety disorders. PASC represents a medical and socio-economic challenge.</p><p><strong>Objectives: </strong>Our study evaluated cytokines (IL-1β, IL-6 and TNFα) and cortisol levels in a cohort of typical patients with PASC, suffering concentration problems, fatigue and difficulties finding words.</p><p><strong>Design: </strong>This was a prospective cohort study. Four groups were analysed and compared: those who had never contracted SARS-CoV-2 (<i>n</i> = 13), infected but had no PASC (<i>n</i> = 34), infected with former PASC that resolved (<i>n</i> = 40) and patients with ongoing PASC after infection (<i>n</i> = 91).</p><p><strong>Methods: </strong>Cytokine and cortisol serum levels were determined in patients' blood samples.</p><p><strong>Results: </strong>Cytokine levels of IL-1β, IL-6, TNFα and cortisol levels did not differ between groups analysed.</p><p><strong>Conclusion: </strong>This may indicate a non-organic/psychosomatic genesis of PASC; further studies are needed to elucidate the underlying causes of PACS, and non-organic causes should not be overlooked.</p>\",\"PeriodicalId\":4,\"journal\":{\"name\":\"ACS Applied Energy Materials\",\"volume\":\"17 \",\"pages\":\"17562864241229567\"},\"PeriodicalIF\":5.4000,\"publicationDate\":\"2024-02-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10860378/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ACS Applied Energy Materials\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1177/17562864241229567\",\"RegionNum\":3,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, PHYSICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Energy Materials","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/17562864241229567","RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}
Cytokines (IL1β, IL6, TNFα) and serum cortisol levels may not constitute reliable biomarkers to identify individuals with post-acute sequelae of COVID-19.
Background: Post-acute sequelae of COVID-19 (PASC) comprise a broad spectrum of symptoms such as fatigue, general weakness, compromised attention and sleep or anxiety disorders. PASC represents a medical and socio-economic challenge.
Objectives: Our study evaluated cytokines (IL-1β, IL-6 and TNFα) and cortisol levels in a cohort of typical patients with PASC, suffering concentration problems, fatigue and difficulties finding words.
Design: This was a prospective cohort study. Four groups were analysed and compared: those who had never contracted SARS-CoV-2 (n = 13), infected but had no PASC (n = 34), infected with former PASC that resolved (n = 40) and patients with ongoing PASC after infection (n = 91).
Methods: Cytokine and cortisol serum levels were determined in patients' blood samples.
Results: Cytokine levels of IL-1β, IL-6, TNFα and cortisol levels did not differ between groups analysed.
Conclusion: This may indicate a non-organic/psychosomatic genesis of PASC; further studies are needed to elucidate the underlying causes of PACS, and non-organic causes should not be overlooked.
期刊介绍：
ACS Applied Energy Materials is an interdisciplinary journal publishing original research covering all aspects of materials, engineering, chemistry, physics and biology relevant to energy conversion and storage. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important energy applications.
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