骨肉瘤患者的微血管密度 (MVD)：系统回顾与元分析》。

IF 1.8 4区医学 Q3 ONCOLOGY

Cancer Investigation Pub Date : 2024-01-01 Epub Date: 2024-02-12 DOI:10.1080/07357907.2024.2311266

Konstantinos Perivoliotis, Panagiotis Ntellas, Katerina Dadouli, Athina A Samara, Sotirios Sotiriou, Maria Ioannou, Konstantinos Tepetes

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引用次数: 0

摘要

我们设计并进行了一项荟萃分析，以估计肿瘤微血管密度（MVD）对骨肉瘤患者生存期的影响。在总生存期（OS）和无病生存期（DFS）方面，高MVD和低MVD之间没有差异。低MVD肿瘤在随访第三年的DFS较低。虽然原发转移瘤不影响平均MVD测量值，但化疗反应良好的肿瘤MVD值较高。虽然在肿瘤MVD、OS和DFS之间没有发现明显差异，但辅助治疗反应良好的肿瘤的血管化模式明显更高。

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Microvessel Density (MVD) in Patients with Osteosarcoma: A Systematic Review and Meta-Analysis.

A meta-analysis was designed and conducted to estimate the effect of tumoral microvessel density (MVD) on the survival of patients with osteosarcoma. There was no difference between high and low MVD regarding the overall (OS) and disease-free (DFS) survival. Low MVD tumors displayed a lower DFS at the third year of follow-up. Although primary metastases did not affect the mean MVD measurements, tumors with a good chemotherapy response had a higher MVD value. Although no significant differences between tumoral MVD, OS and DFS were found, good adjuvant therapy responders had a significant higher vascularization pattern.

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来源期刊

Cancer Investigation 医学-肿瘤学

CiteScore

3.80

自引率

4.20%

发文量

审稿时长

8.5 months

期刊介绍： Cancer Investigation is one of the most highly regarded and recognized journals in the field of basic and clinical oncology. It is designed to give physicians a comprehensive resource on the current state of progress in the cancer field as well as a broad background of reliable information necessary for effective decision making. In addition to presenting original papers of fundamental significance, it also publishes reviews, essays, specialized presentations of controversies, considerations of new technologies and their applications to specific laboratory problems, discussions of public issues, miniseries on major topics, new and experimental drugs and therapies, and an innovative letters to the editor section. One of the unique features of the journal is its departmentalized editorial sections reporting on more than 30 subject categories covering the broad spectrum of specialized areas that together comprise the field of oncology. Edited by leading physicians and research scientists, these sections make Cancer Investigation the prime resource for clinicians seeking to make sense of the sometimes-overwhelming amount of information available throughout the field. In addition to its peer-reviewed clinical research, the journal also features translational studies that bridge the gap between the laboratory and the clinic.