纹状体羟色胺 4 受体在实验性帕金森症和运动障碍中增加

IF 4 3区医学 Q2 NEUROSCIENCES

Journal of Parkinson's disease Pub Date : 2024-01-01 DOI:10.3233/JPD-230331

Rossella Cirillo, Sandra Duperrier, Pathik Parekh, Mathilde Millot, Qin Li, Marie-Laure Thiolat, Micaela Morelli, Jing Xie, Didier Le Bars, Jérôme Redouté, Erwan Bezard, Véronique Sgambato

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引用次数: 0

摘要

血清素 4 型受体水平的改变与多种疾病的情绪障碍和认知缺陷有关。然而，很少有研究调查了运动障碍中的 5-HT4R 改变。我们想知道在实验性帕金森病中纹状体 5-HT4R 的表达是否会发生改变。我们使用了大鼠和猕猴帕金森病（PD）模型的脑库组织。然后，我们在一组猕猴中研究了其体内 PET 成像调节。在这两个模型中，多巴胺能耗竭会增加纹状体 5-HT4R，在运动障碍诱导左旋多巴后会进一步增加。有待在帕金森氏症患者身上得到证实，5-HT4R可能会成为抑制帕金森氏症症状的治疗靶点。

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Striatal Serotonin 4 Receptor is Increased in Experimental Parkinsonism and Dyskinesia.

Alterations of serotonin type 4 receptor levels are linked to mood disorders and cognitive deficits in several conditions. However, few studies have investigated 5-HT4R alterations in movement disorders. We wondered whether striatal 5-HT4R expression is altered in experimental parkinsonism. We used a brain bank tissue from a rat and a macaque model of Parkinson's disease (PD). We then investigated its in vivo PET imaging regulation in a cohort of macaques. Dopaminergic depletion increases striatal 5-HT4R in the two models, further augmented after dyskinesia-inducing L-Dopa. Pending confirmation in PD patients, the 5-HT4R might offer a therapeutic target for dampening PD's symptoms.

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来源期刊

Journal of Parkinson's disease NEUROSCIENCES-

CiteScore

8.40

自引率

5.80%

发文量

338

审稿时长

>12 weeks

期刊介绍： The Journal of Parkinson''s Disease (JPD) publishes original research in basic science, translational research and clinical medicine in Parkinson’s disease in cooperation with the Journal of Alzheimer''s Disease. It features a first class Editorial Board and provides rigorous peer review and rapid online publication.