癌症干细胞：癌症治疗的最新趋势。

IF 1.1 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Nucleosides, Nucleotides & Nucleic Acids Pub Date : 2024-01-01 Epub Date: 2024-02-06 DOI:10.1080/15257770.2024.2311789

Maryam Amiri-Farsani, Zahra Taheri, Somayeh Tirbakhsh Gouran, Omid Chabok, Maryam Safarpour-Dehkordi, Mahsa Kazemi Roudsari

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引用次数: 0

摘要

癌症干细胞（CSCs）是肿瘤细胞的一个亚群，最早在血癌（白血病）中被发现，被认为是癌症治疗中很有希望的治疗靶点。这些细胞是许多恶性肿瘤的病因，包括转移、异质性、耐药性和肿瘤复发。它们通过多种转录程序和信号通路进行这些活动。本综述总结了癌症干细胞的特征，解释了它们的关键信号通路和因子，并讨论了针对癌症干细胞的靶向疗法。研究这些导致治疗失败的机制和信号通路，有助于确定癌症的新治疗途径。

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Cancer stem cells: Recent trends in cancer therapy.

Cancer stem cells (CSCs) are a subset of tumor cells that were first identified in blood cancers (leukemia) and are considered promising therapeutic targets in cancer treatment. These cells are the cause of many malignancies including metastasis, heterogeneity, drug resistance, and tumor recurrence. They carry out these activities through multiple transcriptional programs and signaling pathways. This review summarizes the characteristics of cancer stem cells, explains their key signaling pathways and factors, and discusses targeted therapies for cancer stem cells. Investigating these mechanisms and signaling pathways responsible for treatment failure may help identify new therapeutic pathways in cancer.

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来源期刊

Nucleosides, Nucleotides & Nucleic Acids 生物-生化与分子生物学

CiteScore

2.60

自引率

7.70%

发文量

审稿时长

6 months

期刊介绍： Nucleosides, Nucleotides & Nucleic Acids publishes research articles, short notices, and concise, critical reviews of related topics that focus on the chemistry and biology of nucleosides, nucleotides, and nucleic acids. Complete with experimental details, this all-inclusive journal emphasizes the synthesis, biological activities, new and improved synthetic methods, and significant observations related to new compounds.