前白蛋白、转铁蛋白和白蛋白与老年男性免疫衰老的关系。

IF 2.7 4区 医学 Q3 ENDOCRINOLOGY & METABOLISM
Aging Male Pub Date : 2024-12-01 Epub Date: 2024-02-05 DOI:10.1080/13685538.2024.2310308
Ren-Dan Zhang, Shi-Qin Jiang, Feng-Juan Yan, Lei Ruan, Cun-Tai Zhang, Xiao-Qing Quan
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引用次数: 0

摘要

目的随着年龄的增长,老年人的先天性免疫和获得性免疫都会受到影响,从而导致免疫衰老。前白蛋白(PAB)、转铁蛋白(TRF)和白蛋白(ALB)是监测蛋白质能量营养不良(PEM)的常用指标。然而,它们与免疫系统的关系尚未得到充分探讨:在我们的研究中,2015年1月至2017年2月期间,我们从同济医院共招募了93名受试者(≥65岁)。根据这些蛋白(PAB、TRF 和 ALB)的血清水平,我们将患者分为高血清蛋白组和低血清蛋白组。然后,我们比较了两组淋巴细胞亚群的表达百分比:结果:所有低血清蛋白组(PAB、TRF 和 ALB)的 CD4+ 细胞、CD3+CD28+ 细胞、CD4+CD28+ 细胞的百分比都显著下降,而 CD8+ 细胞、CD8+CD28- 细胞的百分比则显著上升。PAB、TRF和ALB水平与CD4/CD8比率、CD4+细胞比例、CD3+CD28+细胞比例、CD4+CD28+细胞比例呈正相关,与CD8+细胞比例、CD8+CD28-细胞比例呈负相关:本研究表明,PAB、TRF和ALB可作为免疫衰老指标。结论:该研究表明,PAB、TRF和ALB可作为免疫衰老的指标,PEM可能会加速老年男性的免疫衰老过程。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The association of prealbumin, transferrin, and albumin with immunosenescence among elderly males.

Objective: As people get older, the innate and acquired immunity of the elderly are affected, resulting in immunosenescence. Prealbumin (PAB), transferrin (TRF), and albumin (ALB) are commonly used markers to monitor protein energy malnutrition (PEM). However, their relationship with the immune system has not been fully explored.

Methods: In our study, a total of 93 subjects (≥65 years) were recruited from Tongji Hospital between January 2015 and February 2017. According to the serum levels of these proteins (PAB, TRF, and ALB), we divided the patients into the high serum protein group and the low serum protein group. Then, we compared the percent expression of lymphocyte subsets between two groups.

Results: All the low serum protein groups (PAB, TRF, and ALB) had significant decreases in the percentage of CD4+ cells, CD3+CD28+ cells, CD4+CD28+ cells and significant increases in the percentage of CD8+ cells, CD8+CD28- cells. PAB, TRF, and ALB levels revealed positive correlations with CD4/CD8 ratio, proportions of CD4+ cells, CD3+CD28+ cells, CD4+CD28+ cells, and negative correlation with proportions of CD8+ cells, CD8+CD28- cells.

Conclusions: This study suggested PAB, TRF, and ALB could be used as immunosenescence indicators. PEM might accelerate the process of immunosenescence in elderly males.

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来源期刊
Aging Male
Aging Male 医学-泌尿学与肾脏学
CiteScore
6.40
自引率
3.80%
发文量
33
审稿时长
>12 weeks
期刊介绍: The Aging Male , the official journal of the International Society for the Study of the Aging Male, is a multidisciplinary publication covering all aspects of male health throughout the aging process. The Journal is a well-recognized and respected resource for anyone interested in keeping up to date with developments in this field. It is published quarterly in one volume per year. The Journal publishes original peer-reviewed research papers as well as review papers and other appropriate educational material that provide researchers with an integrated perspective on this new, emerging specialty. Areas of interest include, but are not limited to: Diagnosis and treatment of late-onset hypogonadism Metabolic syndrome and related conditions Treatment of erectile dysfunction and related disorders Prostate cancer and benign prostate hyperplasia.
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