突触中的细胞粘附分子信号:超越支架。

IF 6.9 2区 生物学 Q1 CELL BIOLOGY
Ben Verpoort, Joris de Wit
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引用次数: 0

摘要

突触是将突触前后神经元连接成功能神经回路的特化细胞间连接点。突触细胞粘附分子(CAMs)是突触发育过程中的关键角色,它们在突触间隙中进行同嗜性或异嗜性相互作用。数十年的研究已经确定了许多突触细胞粘附分子,绘制了它们的跨突触相互作用图,并确定了它们在协调突触连接中的作用。然而,令人惊讶的是,人们对将跨突触粘附转化为突触前后区室组装的分子机制知之甚少。在此,我们概述了突触 CAMs 参与的细胞内信号通路,并强调了未来工作中有待解决的问题。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Cell Adhesion Molecule Signaling at the Synapse: Beyond the Scaffold.

Synapses are specialized intercellular junctions connecting pre- and postsynaptic neurons into functional neural circuits. Synaptic cell adhesion molecules (CAMs) constitute key players in synapse development that engage in homo- or heterophilic interactions across the synaptic cleft. Decades of research have identified numerous synaptic CAMs, mapped their trans-synaptic interactions, and determined their role in orchestrating synaptic connectivity. However, surprisingly little is known about the molecular mechanisms that translate trans-synaptic adhesion into the assembly of pre- and postsynaptic compartments. Here, we provide an overview of the intracellular signaling pathways that are engaged by synaptic CAMs and highlight outstanding issues to be addressed in future work.

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来源期刊
CiteScore
15.00
自引率
1.40%
发文量
56
审稿时长
3-8 weeks
期刊介绍: Cold Spring Harbor Perspectives in Biology offers a comprehensive platform in the molecular life sciences, featuring reviews that span molecular, cell, and developmental biology, genetics, neuroscience, immunology, cancer biology, and molecular pathology. This online publication provides in-depth insights into various topics, making it a valuable resource for those engaged in diverse aspects of biological research.
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