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引用次数: 0
摘要
阿尔茨海默病(AD)发病率的不断上升导致了一场健康危机。据官方统计,全球有超过 5 500 万人患有阿兹海默症或其他类型的痴呆症,使其成为第六大死因。目前,诊断老年痴呆症仍很困难,还没有明确的诊断方法,尸体解剖仍是唯一确定的方法。此外,临床表现发生在疾病发展过程中的很晚阶段,因此,当疾病显现时,已经发生了深刻的不可逆变化。研究表明,在多发性硬化症的临床前期,一些生物标志物的变化在出现任何神经损伤或其他症状之前就可以测量到。因此,建立一种可靠、快速且经济实惠的方法,能够在早期阶段检测出注意力缺失症,已引起人们的极大关注。为了寻求临床适用、价格低廉、侵入性小且更容易获得的生物标志物用于早期诊断AD,基于血液的生物标志物(BBBs)似乎是一个理想的选择。本综述是对已被证明在AD进展过程中发生改变的BBBs的综合报告。本报告旨在全面介绍基于 BBBs 的 AD 早期检测的研究现状。
Early Diagnosis of Alzheimer's Disease with Blood Test; Tempting but Challenging.
The increasing prevalence of Alzheimer's disease (AD) has led to a health crisis. According to official statistics, more than 55 million people globally have AD or other types of dementia, making it the sixth leading cause of death. It is still difficult to diagnose AD and there is no definitive diagnosis yet; post-mortem autopsy is still the only definite method. Moreover, clinical manifestations occur very late in the course of disease progression; therefore, profound irreversible changes have already occurred when the disease manifests. Studies have shown that in the preclinical stage of AD, changes in some biomarkers are measurable prior to any neurological damage or other symptoms. Hence, creating a reliable, fast, and affordable method capable of detecting AD in early stage has attracted the most attention. Seeking clinically applicable, inexpensive, less invasive, and much more easily accessible biomarkers for early diagnosis of AD, blood-based biomarkers (BBBs) seem to be an ideal option. This review is an inclusive report of BBBs that have been shown to be altered in the course of AD progression. The aim of this report is to provide comprehensive insight into the research status of early detection of AD based on BBBs.
期刊介绍:
The International Journal of Molecular and Cellular Medicine (IJMCM) is a peer-reviewed, quarterly publication of Cellular and Molecular Biology Research Center (CMBRC), Babol University of Medical Sciences, Babol, Iran. The journal covers all cellular & molecular biology and medicine disciplines such as the genetic basis of disease, biomarker discovery in diagnosis and treatment, genomics and proteomics, bioinformatics, computer applications in human biology, stem cells and tissue engineering, medical biotechnology, nanomedicine, cellular processes related to growth, death and survival, clinical biochemistry, molecular & cellular immunology, molecular and cellular aspects of infectious disease and cancer research. IJMCM is a free access journal. All open access articles published in IJMCM are distributed under the terms of the Creative Commons Attribution CC BY. The journal doesn''t have any submission and article processing charges (APCs).