骨髓瘤中的脑隆靶向连接酶降解剂:作用机制与抗药性

IF 2.5 3区 医学 Q2 HEMATOLOGY
Holly Lee MD, MSc, Paola Neri MD, PhD, Nizar J. Bahlis MD
{"title":"骨髓瘤中的脑隆靶向连接酶降解剂:作用机制与抗药性","authors":"Holly Lee MD, MSc, Paola Neri MD, PhD, Nizar J. Bahlis MD","doi":"10.1016/j.hoc.2024.01.001","DOIUrl":null,"url":null,"abstract":"","PeriodicalId":55060,"journal":{"name":"Hematology-Oncology Clinics of North America","volume":null,"pages":null},"PeriodicalIF":2.5000,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Cereblon-Targeting Ligase Degraders in Myeloma\",\"authors\":\"Holly Lee MD, MSc, Paola Neri MD, PhD, Nizar J. Bahlis MD\",\"doi\":\"10.1016/j.hoc.2024.01.001\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"\",\"PeriodicalId\":55060,\"journal\":{\"name\":\"Hematology-Oncology Clinics of North America\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2024-02-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Hematology-Oncology Clinics of North America\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0889858824000017\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"HEMATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Hematology-Oncology Clinics of North America","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0889858824000017","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"HEMATOLOGY","Score":null,"Total":0}
引用次数: 0

摘要

脑龙靶向降解剂,包括免疫调节亚胺类药物来那度胺和泊马度胺,以及脑龙E3连接酶调节剂(如依贝多胺和美昔多胺),已显示出显著的抗骨髓瘤效果。这些药物在多发性骨髓瘤(MM)的多种治疗方法中发挥着重要作用,强调了它们在不同疾病阶段的治疗重要性。尽管来那度胺疗效明显,但约有5%至10%的MM患者对来那度胺表现出原发性耐药性,而且耐药性通常会随着时间的推移而产生。了解该类药物复杂的作用机制和耐药性对于完善和推进新型治疗组合至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Cereblon-Targeting Ligase Degraders in Myeloma
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
CiteScore
4.10
自引率
0.00%
发文量
86
审稿时长
6-12 weeks
期刊介绍: Hematology/Oncology Clinics updates you on the latest trends in patient management, keeps you up to date on the newest advances, and provides a sound basis for choosing treatment options. Under the direction of an experienced guest editor, each issue focuses on a single topic in hematology and oncology, including hemostasis and thrombosis, molecular and cellular basis of hematology, coagulation disorders, and cancers—bone, gastrointestinal, head and neck, lymphomas, neuroendocrine, breast, renal cell, melanoma, and more.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信