Emulgel:局部给药系统的前沿方法。

Q3 Medicine
Anjali Jain, Prashant Kumar, Anurag Verma, Bibhash Chandra Mohanta, Sumel Ashique, Radheshyam Pal, Shubneesh Kumar, Neeraj Mishra
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引用次数: 0

摘要

Emulgel 被认为是一种先进的局部给药系统。由于它同时具有凝胶和乳液的特性,因此具有双重控制药物释放机制的特点。乳胶凝胶能够克服传统外用给药途径存在的问题,如在给药疏水药物时的低延展性和粘性、提高局部作用部位的生物利用度、无油腻质地,以及确保患者的依从性。乳液的使用方式有不含水或含油/含水两种,可将药物加入乳液的适当相中。然后,将乳液加入凝胶相中。油相、胶凝剂和乳化剂等多种因素都会影响药效和稳定性。这一进步不仅有利于皮肤病学,也有利于美容学。目前,以凝胶为基础的制剂被广泛用于抗炎、镇痛、抗痤疮和抗真菌药物的输送。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Emulgel: A Cutting Edge Approach for Topical Drug Delivery System.

Emulgel is considered an advanced leading form of topical drug delivery system. It possesses the quality of a dual control drug mechanism for drug release as it holds the properties of both gel as well as emulsion. Emulgel is capable of overcoming the problems of the conventional route of topical drug delivery, like low spreadability and stickiness with the delivery of hydrophobic drugs, enhanced bioavailability at the local site of action, no greasy texture, and ensuring patient compliance. An emulsion is used either w/o or o/w, and the drug can be incorporated into the suitable phase of the emulsion. After that, the emulsion is incorporated into the gel phase. Several factors like oil phase, gelling agent, and emulsifier can affect the efficacy and stability. This advancement is beneficial not only for dermatology but also for cosmetology as well. Currently, emulgel-based formulations are used for the delivery of anti-inflammatory, analgesic, anti-acne, and antifungal drugs with a wide array of exploration.

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来源期刊
Current Drug Research Reviews
Current Drug Research Reviews Medicine-Psychiatry and Mental Health
CiteScore
3.70
自引率
0.00%
发文量
38
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