炎症在冠状病毒疾病中的作用综述

IF 2 4区医学 Q3 ENDOCRINOLOGY & METABOLISM

Endocrine, metabolic & immune disorders drug targets Pub Date : 2024-02-02 DOI:10.2174/0118715303265274231204075802

Arezoo Lotfi, Pouran Hajian, Laleh Abbasi, Morad Kohandel Gargari, Najmeh Nameh Goshay Fard, Delaram Naderi

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引用次数: 0

摘要

:被称为 COVID-19 的呼吸道疾病是由新型冠状病毒 SARS-CoV-2 引起的。虽然 COVID-19 的确切致病机制尚不清楚，但病毒感染后出现的细胞因子风暴在疾病的发生和发展中起着关键作用。SARS-CoV-2 感染会诱发免疫系统的亢奋状态，导致炎症细胞因子的过度分泌。因此，确定与 COVID-19 诱导的炎症有关的各种信号通路将使研究人员能够研究治疗干预的新目标。

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A Review on the Role of Inflammation in Coronavirus Disease

: The respiratory illness known as COVID-19 is caused by the novel coronavirus, SARS-CoV-2. While the precise pathogenic mechanism of COVID-19 remains unclear, the occurrence of a cytokine storm subsequent to viral infection plays a pivotal role in the initiation and advancement of the disease. The infection of SARS-CoV-2 induces a state of immune system hyperactivity, leading to an excessive production of inflammatory cytokines. Consequently, the identification of the various signaling pathways implicated in the inflammation induced by COVID-19 will enable researchers to investigate new targets for therapeutic intervention.

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来源期刊

Endocrine, metabolic & immune disorders drug targets ENDOCRINOLOGY & METABOLISMIMMUNOLOGY-IMMUNOLOGY

CiteScore

4.60

自引率

5.30%

发文量

217

期刊介绍： Aims & Scope This journal is devoted to timely reviews and original articles of experimental and clinical studies in the field of endocrine, metabolic, and immune disorders. Specific emphasis is placed on humoral and cellular targets for natural, synthetic, and genetically engineered drugs that enhance or impair endocrine, metabolic, and immune parameters and functions. Moreover, the topics related to effects of food components and/or nutraceuticals on the endocrine-metabolic-immune axis and on microbioma composition are welcome.