不同哌嗪类似物的神经药理潜力：最近的一项前瞻性研究

IF 1.9 4区化学 Q2 CHEMISTRY, ORGANIC

Mini-reviews in Organic Chemistry Pub Date : 2024-02-02 DOI:10.2174/0118756298277743231213065544

Mamdouh Allahyani, Mazen Almehmadi, Ahad Amer Alsaiari, Mohammad Asif, Sachin Kumar

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引用次数: 0

摘要

:杂环分子是某些酶和维生素的重要组成部分，在各种生化和酶解过程中发挥着重要作用。哌嗪环是存在于各种知名药物中的杂环分子，通过作用于各种受体，对不同类型的疾病有效。各种哌嗪类似物具有不同的生物活性，特别是在中枢神经系统疾病中，它们涉及激活神经递质受体和靶向各种酶，并具有抗焦虑、抗精神病和抗抑郁等作用。本综述主要介绍哌嗪衍生物及其对不同类型疾病（尤其是神经元疾病）的不同治疗潜力。

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Neuropharmacological Potential of Different Piperazine Analogs: A Recent Prospective

: Heterocyclic moiety is a key part of some enzymes and vitamins and plays a vital role in various biochemical and enzymatic processes. Piperazine ring is a heterocyclic moiety present in various well-known drugs and is effective against different types of diseases by acting on a variety of receptors. Various piperazine analogs possess diverse biological activities, especially in central nervous system disorders, which involve the activation of neurotransmitter receptors and targeting various enzymes and act as antianxiety, antipsychotic, antidepressant, etc. This review is focused on the piperazine derivatives and their diverse therapeutic potential against different types of diseases particularly against neuronal disorders.

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来源期刊

Mini-reviews in Organic Chemistry 化学-有机化学

CiteScore

4.50

自引率

4.30%

发文量

116

审稿时长

>12 weeks

期刊介绍： Mini-Reviews in Organic Chemistry is a peer reviewed journal which publishes original reviews on all areas of organic chemistry including organic synthesis, bioorganic and medicinal chemistry, natural product chemistry, molecular recognition, and physical organic chemistry. The emphasis will be on publishing quality papers very rapidly, without any charges. The journal encourages submission of reviews on emerging fields of organic chemistry including: Bioorganic Chemistry Carbohydrate Chemistry Chemical Biology Chemical Process Research Computational Organic Chemistry Development of Synthetic Methodologies Functional Organic Materials Heterocyclic Chemistry Macromolecular Chemistry Natural Products Isolation And Synthesis New Synthetic Methodology Organic Reactions Organocatalysis Organometallic Chemistry Theoretical Organic Chemistry Polymer Chemistry Stereochemistry Structural Investigations Supramolecular Chemistry