高脂饮食诱导的 PPARδ 在急性早幼粒细胞白血病的发展过程中促进白血病前祖细胞的自我更新

IF 2.9 3区医学 Q2 ONCOLOGY

Cancer Prevention Research Pub Date : 2024-02-02 DOI:10.1158/1940-6207.capr-23-0469

Hiroshi Y. Yamada, Chinthalapally V. Rao

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引用次数: 0

摘要

根据急性早幼粒细胞白血病（APL）与肥胖超重者之间的风险关联，Mazzarella 及其同事假设高脂饮食（HFD）会促进 APL 的发展。作者利用小鼠 APL 模型（PML-RARα 基因敲入）证明，亚油酸能驱动造血祖细胞中 PPARδ 的活化，PPARδ 的活化能增加有 PML-RARA 表达的祖细胞向 APL 的增殖。PPARδ参与干细胞更新和增殖的调控早先在结直肠癌中得到证实，但本研究在造血祖细胞中得到了新的证实，同时建议谨慎使用富含亚油酸的饮食。参见 Mazzarella 等人的相关文章，第 59 页。

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High-Fat Diet Induced PPARδ Promotes Self-renewal of Preleukemic Progenitors in Development of Acute Promyelocytic Leukemia

From risk association between acute promyelocytic leukemia (APL) and obese-overweight individuals, Mazzarella and colleagues hypothesized that a high-fat diet (HFD) promotes development of APL. Using mouse APL model (PML-RARα knock-in), the authors demonstrated that linoleic acid drives activation of PPARδ in hematopoietic progenitors, and that activation of PPARδ increases proliferation of progenitor cells with PML-RARA expression toward APL. Involvements of PPARδ on regulation of stem cell renewal and proliferation were shown in colorectal cancers earlier, but this study newly demonstrates in hematopoietic progenitors, while suggesting use of diet rich in linoleic acid with caution. See related article by Mazzarella et al., p. 59

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来源期刊

Cancer Prevention Research 医学-肿瘤学

CiteScore

6.00

自引率

3.00%

发文量

173

审稿时长

1 months

期刊介绍： Cancer Prevention Research publishes original studies, reviews, and perspectives in the field of cancer prevention. Its scope includes the molecular and cellular biology of premalignancy and early lesions; genetic and environmental risk factors; risk assessment and reduction; early detection research (cancer screening and diagnosis); and preventive interventions (chemoprevention, immunoprevention, and others) to intercept cancer development at early stages prior to initiation, promotion, or progression. The journal comprises preclinical, clinical, and translational research, with special attention given to molecular discoveries and an emphasis on building a translational bridge between the basic and clinical sciences.