K Koike, E Yoshida, K Katagiri, M Katayanagi, M Oda, H Tsunoo, K Yaginuma, M Kobayashi
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Production of hepatitis B virus surface antigen particles by the human hepatoma cell line huGK-14 in a serum-free medium.
The human hepatoma cell line, huGK-14, containing integrated hepatitis B virus (HBV) DNAs, produced a large number of 23 nm spherical particles of HBV surface antigen (HBsAg) in a serum-free medium. These particles closely resembled the HBsAg particles found in the sera of HBV carriers and elicited a high antibody response in guinea pigs. The huGK-14 cells in a serum-free medium would provide a new, economic source of HBV vaccine.
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