Arjen-Kars Boer, Ruben Deneer, Maaike Maas, Heidi Ammerlaan, Roland H.H. van Balkom, Mathie PG Leers, Remy J.H. Martens, Madelon M. Buijs, Jos J. Kerremans, Muriël Messchaert, Jeroen D.E. van Suijlen, Natal A.W. van Riel, Volkher Scharnhorst
{"title":"一项多中心病例对照研究：CoLab-评分可在急诊科快速有效地排除 COVID-19，而无需进行 SARS-CoV-2 检测","authors":"Arjen-Kars Boer, Ruben Deneer, Maaike Maas, Heidi Ammerlaan, Roland H.H. van Balkom, Mathie PG Leers, Remy J.H. Martens, Madelon M. Buijs, Jos J. Kerremans, Muriël Messchaert, Jeroen D.E. van Suijlen, Natal A.W. van Riel, Volkher Scharnhorst","doi":"10.1101/2024.01.30.24301996","DOIUrl":null,"url":null,"abstract":"Background<br />Rapid identification of emergency department (ED) patients with a possible COVID-19 infection is needed. PCR-testing all ED patients is neither feasible nor effective in most centers, therefore a rapid, objective, low-cost screening tool to triage ED patients is necessary.<br />Methods<br />Results from all routine lab tests from ED patients at the Catharina Hospital were collected from July 2019 to July 2020 and used in a statistical model to obtain the CoLab-score. The score was validated temporally and externally in three independent centers.<br />Results<br />The CoLab-score consists of 10 routine lab results and can be used to safely rule-out a COVID-19 infection in more than one third of ED presentations with a negative predictive value of 0.997 (95% CI: 0.994 – 0.999) .<br />Conclusions<br />The CoLab-score is a valuable tool to rule out COVID-19, guide PCR testing and is available to any center with access to routine laboratory tests.","PeriodicalId":501290,"journal":{"name":"medRxiv - Emergency Medicine","volume":"61 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The CoLab-score rapidly and efficiently excludes COVID-19 at the emergency department without need for SARS-CoV-2 testing: a multicenter case-control study\",\"authors\":\"Arjen-Kars Boer, Ruben Deneer, Maaike Maas, Heidi Ammerlaan, Roland H.H. van Balkom, Mathie PG Leers, Remy J.H. Martens, Madelon M. Buijs, Jos J. Kerremans, Muriël Messchaert, Jeroen D.E. van Suijlen, Natal A.W. van Riel, Volkher Scharnhorst\",\"doi\":\"10.1101/2024.01.30.24301996\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Background<br />Rapid identification of emergency department (ED) patients with a possible COVID-19 infection is needed. PCR-testing all ED patients is neither feasible nor effective in most centers, therefore a rapid, objective, low-cost screening tool to triage ED patients is necessary.<br />Methods<br />Results from all routine lab tests from ED patients at the Catharina Hospital were collected from July 2019 to July 2020 and used in a statistical model to obtain the CoLab-score. The score was validated temporally and externally in three independent centers.<br />Results<br />The CoLab-score consists of 10 routine lab results and can be used to safely rule-out a COVID-19 infection in more than one third of ED presentations with a negative predictive value of 0.997 (95% CI: 0.994 – 0.999) .<br />Conclusions<br />The CoLab-score is a valuable tool to rule out COVID-19, guide PCR testing and is available to any center with access to routine laboratory tests.\",\"PeriodicalId\":501290,\"journal\":{\"name\":\"medRxiv - Emergency Medicine\",\"volume\":\"61 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-01-31\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"medRxiv - Emergency Medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1101/2024.01.30.24301996\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"medRxiv - Emergency Medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1101/2024.01.30.24301996","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
The CoLab-score rapidly and efficiently excludes COVID-19 at the emergency department without need for SARS-CoV-2 testing: a multicenter case-control study
Background<br />Rapid identification of emergency department (ED) patients with a possible COVID-19 infection is needed. PCR-testing all ED patients is neither feasible nor effective in most centers, therefore a rapid, objective, low-cost screening tool to triage ED patients is necessary.<br />Methods<br />Results from all routine lab tests from ED patients at the Catharina Hospital were collected from July 2019 to July 2020 and used in a statistical model to obtain the CoLab-score. The score was validated temporally and externally in three independent centers.<br />Results<br />The CoLab-score consists of 10 routine lab results and can be used to safely rule-out a COVID-19 infection in more than one third of ED presentations with a negative predictive value of 0.997 (95% CI: 0.994 – 0.999) .<br />Conclusions<br />The CoLab-score is a valuable tool to rule out COVID-19, guide PCR testing and is available to any center with access to routine laboratory tests.
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