多囊卵巢综合症药物开发的基因和表观遗传学前景。

IF 22 1区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Yi Chen, Guiquan Wang, Jingqiao Chen, Congying Wang, Xi Dong, Hsun-Ming Chang, Shuai Yuan, Yue Zhao, Liangshan Mu
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引用次数: 0

摘要

多囊卵巢综合症(PCOS)的治疗面临挑战,因为所有已知的治疗方法都只是对症治疗。美国食品和药物管理局(FDA)尚未批准任何专门用于治疗多囊卵巢综合症的药物。随着遗传学和表观遗传学在药物开发中的重要性不断提高,它们的重要见解大大提高了药物靶点发现和验证的效率和成功率,为指导多囊卵巢综合症治疗的进步带来了希望。在此背景下,我们概述了多囊卵巢综合症的遗传学和表观遗传学进展,这些进展为这一复杂疾病的发病机制提供了新的见解。我们还深入探讨了利用基因和表观遗传学策略识别潜在药物靶点并确保靶点安全性的前瞻性方法。此外,我们还阐明了与多囊卵巢综合症相关的基因和表观遗传疗法的初步证据和独特挑战。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Genetic and Epigenetic Landscape for Drug Development in Polycystic Ovary Syndrome.

The treatment of polycystic ovary syndrome (PCOS) faces challenges as all known treatments are merely symptomatic. The US Food and Drug Administration has not approved any drug specifically for treating PCOS. As the significance of genetics and epigenetics rises in drug development, their pivotal insights have greatly enhanced the efficacy and success of drug target discovery and validation, offering promise for guiding the advancement of PCOS treatments. In this context, we outline the genetic and epigenetic advancement in PCOS, which provide novel insights into the pathogenesis of this complex disease. We also delve into the prospective method for harnessing genetic and epigenetic strategies to identify potential drug targets and ensure target safety. Additionally, we shed light on the preliminary evidence and distinctive challenges associated with gene and epigenetic therapies in the context of PCOS.

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来源期刊
Endocrine reviews
Endocrine reviews 医学-内分泌学与代谢
CiteScore
42.00
自引率
1.00%
发文量
29
期刊介绍: Endocrine Reviews, published bimonthly, features concise timely reviews updating key mechanistic and clinical concepts, alongside comprehensive, authoritative articles covering both experimental and clinical endocrinology themes. The journal considers topics informing clinical practice based on emerging and established evidence from clinical research. It also reviews advances in endocrine science stemming from studies in cell biology, immunology, pharmacology, genetics, molecular biology, neuroscience, reproductive medicine, and pediatric endocrinology.
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