{"title":"进化的优势：免疫中的 NOD 样受体","authors":"Aila Akosua Kattner","doi":"10.1016/j.bj.2024.100702","DOIUrl":null,"url":null,"abstract":"<div><p>This issue of the <em>Biomedical Journal</em> delves into the multifaceted roles of NOD-like receptors (NLRs) in immunity, examining their subfamilies and functions within innate and adaptive immunity, autoimmune and inflammatory conditions, and mitophagy regulation. In this issue the dynamics of mRNA vaccines are explored, as well as the synergistic effects of a ketogenic diet with anti-tumor therapies, the roles of curcumin and RANKL in osteoclastogenesis, and the validation of a rapid diagnostic test for an oral cancer biomarker. Additionally, advancements in ocular care are highlighted, featuring a novel prodrug targeting corneal neovascularization, and discussing the efficacy of dexamethasone implants against macular edema. Concluding, further insights into the impact of sweetened foods on child development are given.</p></div>","PeriodicalId":8934,"journal":{"name":"Biomedical Journal","volume":"47 1","pages":"Article 100702"},"PeriodicalIF":4.1000,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2319417024000052/pdfft?md5=17851b6eeab99c8bc110fde5d62d26e3&pid=1-s2.0-S2319417024000052-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Evolutionary edge: NOD-like receptors in immunity\",\"authors\":\"Aila Akosua Kattner\",\"doi\":\"10.1016/j.bj.2024.100702\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>This issue of the <em>Biomedical Journal</em> delves into the multifaceted roles of NOD-like receptors (NLRs) in immunity, examining their subfamilies and functions within innate and adaptive immunity, autoimmune and inflammatory conditions, and mitophagy regulation. In this issue the dynamics of mRNA vaccines are explored, as well as the synergistic effects of a ketogenic diet with anti-tumor therapies, the roles of curcumin and RANKL in osteoclastogenesis, and the validation of a rapid diagnostic test for an oral cancer biomarker. Additionally, advancements in ocular care are highlighted, featuring a novel prodrug targeting corneal neovascularization, and discussing the efficacy of dexamethasone implants against macular edema. Concluding, further insights into the impact of sweetened foods on child development are given.</p></div>\",\"PeriodicalId\":8934,\"journal\":{\"name\":\"Biomedical Journal\",\"volume\":\"47 1\",\"pages\":\"Article 100702\"},\"PeriodicalIF\":4.1000,\"publicationDate\":\"2024-02-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S2319417024000052/pdfft?md5=17851b6eeab99c8bc110fde5d62d26e3&pid=1-s2.0-S2319417024000052-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biomedical Journal\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2319417024000052\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biomedical Journal","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2319417024000052","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
This issue of the Biomedical Journal delves into the multifaceted roles of NOD-like receptors (NLRs) in immunity, examining their subfamilies and functions within innate and adaptive immunity, autoimmune and inflammatory conditions, and mitophagy regulation. In this issue the dynamics of mRNA vaccines are explored, as well as the synergistic effects of a ketogenic diet with anti-tumor therapies, the roles of curcumin and RANKL in osteoclastogenesis, and the validation of a rapid diagnostic test for an oral cancer biomarker. Additionally, advancements in ocular care are highlighted, featuring a novel prodrug targeting corneal neovascularization, and discussing the efficacy of dexamethasone implants against macular edema. Concluding, further insights into the impact of sweetened foods on child development are given.
期刊介绍：
Biomedical Journal publishes 6 peer-reviewed issues per year in all fields of clinical and biomedical sciences for an internationally diverse authorship. Unlike most open access journals, which are free to readers but not authors, Biomedical Journal does not charge for subscription, submission, processing or publication of manuscripts, nor for color reproduction of photographs.
Clinical studies, accounts of clinical trials, biomarker studies, and characterization of human pathogens are within the scope of the journal, as well as basic studies in model species such as Escherichia coli, Caenorhabditis elegans, Drosophila melanogaster, and Mus musculus revealing the function of molecules, cells, and tissues relevant for human health. However, articles on other species can be published if they contribute to our understanding of basic mechanisms of biology.
A highly-cited international editorial board assures timely publication of manuscripts. Reviews on recent progress in biomedical sciences are commissioned by the editors.
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