被迫恢复原状：上皮伤口修复机制

IF 6 2区生物学 Q1 CELL BIOLOGY

Current Opinion in Cell Biology Pub Date : 2024-01-30 DOI:10.1016/j.ceb.2024.102324

Shu En Lim , Pablo Vicente-Munuera , Yanlan Mao

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引用次数: 0

摘要

伤口修复，即堵住一个洞，本质上是一个物理过程，需要改变材料的形状，这里指的是细胞和组织。高效准确的伤口修复不仅对恢复屏障功能和减少感染至关重要，而且对恢复器官复杂的三维结构也至关重要。这种组织重塑需要细胞行为在空间和时间上多维度的复杂协调，以确保修复后的结构能继续发挥最佳功能。最新证据表明，二维和三维的细胞和组织力学对实现这种无缝伤口修复非常重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Forced back into shape: Mechanics of epithelial wound repair

Wound repair, the closing of a hole, is inherently a physical process that requires the change of shape of materials, in this case, cells and tissues. Not only is efficient and accurate wound repair critical for restoring barrier function and reducing infection, but it is also critical for restoring the complex three-dimensional architecture of an organ. This re-sculpting of tissues requires the complex coordination of cell behaviours in multiple dimensions, in space and time, to ensure that the repaired structure can continue functioning optimally. Recent evidence highlights the importance of cell and tissue mechanics in 2D and 3D to achieve such seamless wound repair.

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来源期刊

Current Opinion in Cell Biology 生物-细胞生物学

CiteScore

14.60

自引率

1.30%

发文量

审稿时长

93 days

期刊介绍： Current Opinion in Cell Biology (COCEBI) is a highly respected journal that specializes in publishing authoritative, comprehensive, and systematic reviews in the field of cell biology. The journal's primary aim is to provide a clear and readable synthesis of the latest advances in cell biology, helping specialists stay current with the rapidly evolving field. Expert authors contribute to the journal by annotating and highlighting the most significant papers from the extensive body of research published annually, offering valuable insights and saving time for readers by distilling key findings. COCEBI is part of the Current Opinion and Research (CO+RE) suite of journals, which leverages the legacy of editorial excellence, high impact, and global reach to ensure that the journal is a widely read resource integral to scientists' workflow. It is published by Elsevier, a publisher known for its commitment to excellence in scientific publishing and the communication of reproducible biomedical research aimed at improving human health. The journal's content is designed to be an invaluable resource for a diverse audience, including researchers, lecturers, teachers, professionals, policymakers, and students.