S Magasiny, B Spire, F Rey, F Barre-Sinoussi, J C Chermann
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引用次数: 0
摘要
LAV/HTLV-III已被发现是艾滋病的病因。这种新的人类逆转录病毒对OKT4/leu 3亚群的T淋巴细胞具有选择性趋向性，从而诱导细胞病变作用。我们比较了来自不同个体的整合前病毒dna的Southern blot模式，这些个体有风险或没有使用标记翻译的LAV探针。我们发现LAV/HTLV-III与我们的海地分离株非常相似，与纽约早期发现的(1982年)艾滋病病例的分离株接近。当我们使用Hind III或Bgl II sac消化片段时，Zaïrian分离株以及来自非高危组的分离株的差异更明显。我们还研究了从西西里儿童身上分离的病毒，该儿童在接受同种异体骨髓移植和输血后患上了艾滋病。这种分离显示了两种形式:一种与原型LAV相似，另一种则大不相同。
LAV/HTLV-III has been found to be the etiological cause of AIDS. This new human retrovirus has a selective tropism for T lymphocytes of the OKT4/leu 3 subset, in which it induces a cytopathic effect. We have compared Southern blot patterns of integrated proviral DNAs from different individuals at risk or not using a nick-translated LAV probe. We find that LAV/HTLV-III is very similar to our Haitian isolate and close to an isolate from an early-recognized (in 1982) AIDS case in New York. More variation is apparent with Zaïrian isolates as well as an isolate from a nonhigh-risk group when we used Hind III or Bgl II Sac-digested fragments. We also looked at virus isolated from a Sicilian child who developed AIDS after allogenic bone marrow transplant and transfusion. This isolate shows two forms: One is similar to the prototype LAV, the second much different.
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