接受减肥手术的 II 型糖尿病患者术前 24 小时暂停服用 SGLT2 抑制剂对缓解优格症糖尿病酮症酸中毒的疗效。

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-01-24 DOI:10.1016/j.deman.2024.100201

Samer Younes

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引用次数: 0

摘要

该病例强调了减肥手术和使用 SGLT2 抑制剂后发生优生糖尿病酮症酸中毒 (DKA) 的风险，突出了患者教育和医疗服务提供者监控的重要性。潜在的原因包括 SGLT2 抑制剂导致尿糖排泄增加、术后碳水化合物摄入减少以及可能的胰岛素停药效应。目前 AACE 建议在手术前 24 小时停用 SGLT2 抑制剂，这可能需要更多的研究来确定最佳停药时间。

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The efficacy of a 24-hour preoperative pause for SGLT2-inhibitors in type II diabetes patients undergoing bariatric surgery to mitigate euglycemic diabetic ketoacidosis

The case emphasizes the risk of euglycemic diabetic ketoacidosis (DKA) after bariatric surgery and SGLT2 inhibitor use, highlighting the importance of patient education and healthcare provider monitoring. Potential causes include increased urinary glucose excretion from SGLT2 inhibitors, reduced carbohydrate intake post-surgery, and possible insulin discontinuation effects. The current recommendation from AACE to discontinue SGLT2 inhibitors 24 h before surgery may require additional research to determine the optimal timing of discontinuation.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.