用于骨组织工程的三维打印聚羟基烷酸酯基微生物支架的仿生矿化作用

IF 6.8 3区医学 Q1 ENGINEERING, BIOMEDICAL

International Journal of Bioprinting Pub Date : 2024-01-16 DOI:10.36922/ijb.1806

Dahong Kim, Su Jeong Lee, Dongjin Lee, Ji Min Seok, Seon Ju Yeo, Hyungjun Lim, Jae Jong Lee, Jae Hwang Song, Kangwon Lee, Won Ho Park, Su A Park

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引用次数: 0

摘要

聚羟基烷酸酯（PHA）具有生物相容性和生物可降解性等多种优势，是传统塑料骨支架的潜在替代品，因此备受关注。然而，PHA 的耐水性会造成干扰细胞相互作用的环境。在本研究中，考虑到 PHA 的物理特性，通过熔融沉积建模打印技术制作了三维打印 PHA 支架。然后，采用相对简单、快速的浸泡工艺，在 PHA 骨支架上涂覆各种配置的聚多巴胺（pDA）和/或羟基磷灰石（HA）。PHA-pDA- HA 支架显示出更强的细胞活力、增殖和分化能力，因此可作为骨组织工程应用的多功能平台。

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Biomimetic mineralization of 3D-printed polyhydroxyalkanoate-based microbial scaffolds for bone tissue engineering

Polyhydroxyalkanoates (PHAs) have gained much attention as a potential alternative to conventional plastic bone scaffolds due to their biocompatibility and biodegradability, among a diverse range of advantageous properties. However, the water resistance of PHA creates an environment that can interfere with cell interactions. In this study, a three-dimensional-printed PHA scaffold was fabricated through fused deposition modeling printing considering the physical properties of PHA. The PHA bone scaffolds were then coated with polydopamine (pDA) and/or hydroxyapatite (HA) in various configurations using a relatively simple and rapid process involving only immersion. The PHA–pDA– HA scaffold showed enhanced cell viability, proliferation, and differentiation, and could thus serve as a versatile platform for bone tissue engineering applications.

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来源期刊

International Journal of Bioprinting Multiple-

CiteScore

6.90

自引率

4.80%

发文量

期刊介绍： The International Journal of Bioprinting is a globally recognized publication that focuses on the advancements, scientific discoveries, and practical implementations of Bioprinting. Bioprinting, in simple terms, involves the utilization of 3D printing technology and materials that contain living cells or biological components to fabricate tissues or other biotechnological products. Our journal encompasses interdisciplinary research that spans across technology, science, and clinical applications within the expansive realm of Bioprinting.