聚氧化乙烯和聚氧化丙烯嵌段共聚物生产和工业应用回顾分析(综述)

E. Bakhrushina, V. S. Pyzhov, P. Sakharova, N. Demina, I. Krasnyuk
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摘要

简介。如今,PEO 和 PPO 嵌段共聚物(poloxamers、pluronics、proxanols)是制药和生物技术行业最受欢迎的聚合物之一。它们可用作有效的非离子表面活性剂、生物膜稳定剂、靶向给药系统元件、增溶剂以及传统剂型技术中的赋形剂--胶凝剂、润滑剂等。过去五十年来,世界上最大的多羟酰胺生产商一直是德国巴斯夫化学公司。然而,如今在俄罗斯联邦存在着缺陷风险,这就决定了进口替代这种辅料的重要性。本综述的目的是重点介绍俄罗斯科学家在新型 PEO 和 PPO 嵌段共聚物的生产和应用方面的经验,并将其与国外研究小组的经验进行比较,这对于评估进口替代的潜力非常必要。苏联早在 60 年代末期就已经知道 PEO 和 PPO 嵌段共聚物,1964 年和 1973 年的教科书中都有提及。国内的 PEO 和 PPO 嵌段共聚物已用于炼油工业、轻工业的某些部门以及放射性废物的净化。1978 年,在 "Orgsintez "工厂的基础上建立了国内独一无二的 PEO 和 PPO 嵌段共聚物合成技术。苏联以 "proxanol "为商标生产聚氧化酰胺,其 EO 和 PO 单位的比例和分子量范围很广。值得注意的是,如今在俄罗斯联邦,仍在生产工业批量生产的增溶剂 Emuxol 268(其性质与著名的聚氧乙烯酰胺 188 相似),并根据订单合成具有其他 EO 和 PO 单元比例的嵌段共聚物。根据回顾性分析,现代俄罗斯工业拥有足够的经验和资源来合成生产药物和开发创新给药系统和药物所需的 PEO 和 PPO 嵌段共聚物。在系统回顾材料的基础上,首次汇编了我国和世界上在过去 50 年中合成的 PEO 和 PPO 嵌段共聚物已知品牌的最完整登记册,并详细描述了它们的物理化学特性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Retrospective Analysis of Polyethylene Oxide and Polypropylene Oxide Block Copolymers Production and Industrial Applications (Review)
Introduction. Nowadays block copolymers of PEO and PPO (poloxamers, pluronics, proxanols) are among the most popular polymers in the pharmaceutical and biotechnological industries. They can be applied as effective nonionic surfactants, biological membrane stabilizers, elements of targeted delivery systems, solubilizers, as well as excipients in the technology of traditional dosage forms – gelling agents, lubricants, etc. For the past fifty years, the world's largest manufacturer of poloxamers has been the German chemical concern BASF. However, today in the Russian Federation there is a risk of defects, which defines the relevance of import substitution of this excipient.Text. The purpose of this review is to highlight the experience of production and implementation of PEO and PPO block copolymers into novel Russian scientists’ developments, comparing them with the experience of foreign research groups, which is necessary to assess the potential for import substitution. PEO and PPO block copolymers have been known in the Soviet Union since the late 60s as far as they are mentioned in textbooks of 1964 and 1973. Domestic block copolymers of PEO and PPO have been used in the oil refining industry, as well as in some branches of light industry and in the decontamination of radioactive waste. The unique domestic synthesis of PEO and PPO block copolymers was established in 1978 on the basis of the "Orgsintez" factory. Soviet poloxamers were produced under the brand name "proxanol" in a wide range of ratios of EO and PO units and molecular weights. It should be noted that today in the Russian Federation, industrial batches of the solubilizer Emuxol 268, which is close in its properties to the well-known poloxamer 188, are still produced, and block copolymers with other ratios of EO and PO units are synthesized to order.Conclusion. According to the retrospective analysis, the modern Russian industry has enough experience and resources to establish the synthesis of PEO and PPO block copolymers necessary to produce drugs and to develop innovative delivery systems and drugs. Based on the materials of the systematic review, the most complete register of known brands of PEO and PPO block copolymers synthesized over the past 50 years in our country and in the world was compiled for the first time, with a detailed description of their physicochemical properties.
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