Teenu sharma, M. A. Babu, Atul Jain, Deepika Sharma
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Lipid-based Nanocarriers for mRNA Delivery: Vital Considerations and
Applications
The use of mRNA in therapeutics has lately emerged as a powerful strategy for alleviating
the various viral infections and diseased conditions, along with prophylaxis. However, a key challenge
in their efficient delivery is the protection of the nucleic acid from degradation followed by
mRNA transport to the cells. In this regard, clinical translation of mRNA therapeutics has largely
been facilitated with the advent of lipid-based nanoparticles (LBNPs). LBNPs–mRNA vaccines currently
being employed for Covid 19 is one such instance substantiating and endorsing the use of
lipidic nanocarriers for mRNA therapeutics. Thus, the current review article aims to furnish information
on developmental challenges, different aspects of lipid-based carrier systems for mRNA delivery,
their vital applications in different diseases and the future potential of LBNPs in therapeutics.
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