轻松合成具有类似催化剂活性的纳米颗粒-堆叠 Co3O4 纳米片,加速伤口愈合

IF 5.6 1区 医学 Q1 MATERIALS SCIENCE, BIOMATERIALS
Yanan Huang, Wanyi Liao, Wenxuan Wang, Tingting Zhang, Yan Zhang, Lei Lu
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引用次数: 0

摘要

活性氧(ROS)过多导致的伤口延迟愈合仍然是一个相当大的挑战。近年来,金属氧化物纳米酶在生物医学研究中获得了极大关注。然而,目前还缺乏对基于 Co3O4 的纳米酶在促进伤口愈合和组织再生方面的全面研究。本研究的重点是开发一种简便的合成方法,以制备具有类似过氧化氢酶(CAT)活性的高稳定性和高成本效益的 Co3O4 纳米片(NFs),从而调节氧化微环境并加速伤口愈合。与市售的 Co3O4 NPs 相比,NFs 结构中紧密排列的 Co3O4 纳米颗粒(NPs)可显著增大表面积,从而提高酶活性。据观察,在生理条件下,Co3O4 NFs 能有效分解过氧化氢(H2O2),而不会产生有害自由基(-OH)。此外,Co3O4 NFs 还能与参与伤口愈合的各种细胞产生良好的相容性,促进成纤维细胞的生长,保护细胞免受氧化应激。在大鼠模型中,Co3O4 NFs 可促进伤口愈合的止血和增殖阶段,从而加速伤口愈合过程。总之,Co3O4 NFs 的研究结果令人鼓舞,凸显了其在促进伤口愈合和组织再生方面的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Facile synthesis of Nanoparticles-Stacked Co3O4 nanoflakes with catalase-like activity for accelerating wound healing
Delayed wound healing caused by excessive reactive oxygen species (ROS) remains a considerable challenge. In recent years, metal oxide nanozymes have gained significant attention in biomedical research. However, a comprehensive investigation of Co3O4 based nanozymes for enhancing wound healing and tissue regeneration is lacking. This study focuses on developing a facile synthesis method to produce high-stability and cost-effective Co3O4 nanoflakes (NFs) with promising catalase (CAT)-like activity to regulate the oxidative microenvironment and accelerate wound healing. The closely arranged Co3O4 nanoparticles (NPs) within the NFs structure result in a significantly larger surface area, thereby amplifying the enzymatic activity compared to commercially available Co3O4 NPs. Under physiological conditions, it was observed that Co3O4 NFs efficiently break down hydrogen peroxide (H2O2) without generating harmful radicals (·OH). Moreover, they exhibit excellent compatibility with various cells involved in wound healing, promoting fibroblast growth and protecting cells from oxidative stress. In a rat model, Co3O4 NFs facilitate both the hemostatic and proliferative phases of wound healing, consequently accelerating the process. Overall, the promising results of Co3O4 NFs highlight their potential in promoting wound healing and tissue regeneration.
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来源期刊
Regenerative Biomaterials
Regenerative Biomaterials Materials Science-Biomaterials
CiteScore
7.90
自引率
16.40%
发文量
92
审稿时长
10 weeks
期刊介绍: Regenerative Biomaterials is an international, interdisciplinary, peer-reviewed journal publishing the latest advances in biomaterials and regenerative medicine. The journal provides a forum for the publication of original research papers, reviews, clinical case reports, and commentaries on the topics relevant to the development of advanced regenerative biomaterials concerning novel regenerative technologies and therapeutic approaches for the regeneration and repair of damaged tissues and organs. The interactions of biomaterials with cells and tissue, especially with stem cells, will be of particular focus.
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