邻碘芳香族醚的简易合成和抗肿瘤活性

IF 0.7 4区化学 Q4 CHEMISTRY, ORGANIC

Letters in Organic Chemistry Pub Date : 2024-01-29 DOI:10.2174/0115701786262911240121105544

Xiaoxia Mao, Yuying Zhang, Keyang Wang, Guiqin Zhao, Dejun Zhou, Zhengguo Cui

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引用次数: 0

摘要

:本研究介绍了一种合成芳香族醚的有效方法，并对其抗肿瘤活性进行了研究。具体来说，以 2-甲基碘苯为原料制备（二乙酰氧基碘）炔，并用其氧化 4-硝基苯酚，得到芳香族醚。我们的研究进一步发现，芳香醚对 U937 单核细胞有很强的凋亡作用，这表明芳香醚有可能被开发成治疗急性髓性白血病的新药。

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Facile Synthesis and Antitumor Activity of o-Iodoaromatic Ether

: In this study, an efficient method for the synthesis of one type of aromatic ether was introduced, and its antitumor activity was investigated. Specifically, (diacetoxyiodo)arene was prepared from 2-methyliodobenzene and used to oxidize the 4-nitrophenol to give the aromatic ether. Our study further found that aromatic ether has a strong apoptotic effect on U937 monocytes, suggesting that it might be developed as a new drug for the treatment of acute myeloid leukemia.

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来源期刊

Letters in Organic Chemistry 化学-有机化学

CiteScore

1.30

自引率

12.50%

发文量

135

审稿时长

7 months

期刊介绍： Aims & Scope Letters in Organic Chemistry publishes original letters (short articles), research articles, mini-reviews and thematic issues based on mini-reviews and short articles, in all areas of organic chemistry including synthesis, bioorganic, medicinal, natural products, organometallic, supramolecular, molecular recognition and physical organic chemistry. The emphasis is to publish quality papers rapidly by taking full advantage of latest technology for both submission and review of the manuscripts. The journal is an essential reading for all organic chemists belonging to both academia and industry.