内窥镜超声引导下的组织采集，用于全面基因组分析。

IF 1.9 4区医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Journal of Medical Ultrasonics Pub Date : 2024-04-01 Epub Date: 2024-01-28 DOI:10.1007/s10396-023-01403-x

Nozomi Okuno, Kazuo Hara

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引用次数: 0

摘要

下一代测序技术的进步使得利用肿瘤组织标本和血液样本进行全面基因组分析（CGP）在常规临床实践中变得可行。就胰胆管癌而言，在制定个体化治疗策略时有必要考虑 CGP。利用肿瘤组织标本进行 CGP 需要足够数量的高质量样本。预计 EUS 引导下的组织采集（EUS-TA）将在这方面发挥重要作用，内镜医师需要解决这一问题。在此，我们以胰腺癌和胆道癌为重点，回顾了 EUS-TA 用于 CGP 的现状。

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Endoscopic ultrasound-guided tissue acquisition for comprehensive genomic profiling.

Advances in next-generation sequencing have made comprehensive genomic profiling (CGP) using tumor tissue specimens and liquid biopsy using blood samples feasible in routine clinical practice. In the context of pancreaticobiliary cancer, it is necessary to consider CGP in formulating individualized treatment strategies. Performing CGP with tumor tissue specimens requires a sufficient number of high-quality samples. EUS-guided tissue acquisition (EUS-TA) is expected to play a significant role in this regard, and endosonographers need to address this role. Here, we review the current status of EUS-TA for CGP focusing on pancreatic cancer and biliary tract cancer.

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来源期刊

Journal of Medical Ultrasonics 医学-核医学

CiteScore

3.30

自引率

11.10%

发文量

102

审稿时长

>12 weeks

期刊介绍： The Journal of Medical Ultrasonics is the official journal of the Japan Society of Ultrasonics in Medicine. The main purpose of the journal is to provide forum for the publication of papers documenting recent advances and new developments in the entire field of ultrasound in medicine and biology, encompassing both the medical and the engineering aspects of the science.The journal welcomes original articles, review articles, images, and letters to the editor.The journal also provides state-of-the-art information such as announcements from the boards and the committees of the society.