合并感染结核病和组织胞浆菌病的艾滋病病毒感染者的临床特征、诊断、治疗和预后:5 年回顾性病例系列。

IF 1.9 4区 医学 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
María Eugenia Castellanos Reynosa, Maria Eugenia Caal, Danicela Mercado, Narda Medina, Juan Carlos Pérez, Theophilus I Emeto, Eduardo Arathoon
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引用次数: 0

摘要

背景:在拉丁美洲,结核病(TB)和组织胞浆菌病是影响人类免疫缺陷病毒(HIV)感染者最常见的两种机会性感染。然而,关于同时感染结核病和组织胞浆菌病的患者的临床特征和治疗效果的数据却很有限:这是一项回顾性观察研究,旨在描述 2017 年至 2021 年期间在危地马拉危地马拉城被诊断为同时患有组织胞浆菌病和肺结核的 21 名艾滋病病毒感染者(PLHIV)的临床、流行病学和实验室特征及结果:大多数患者为男性,并且是新诊断出的艾滋病毒感染者。所有患者都患有晚期艾滋病(AHD)。他们的 CD4 细胞计数中位数为 20 cells/µl。患者最常见的症状是发烧、体重减轻、咳嗽和腹泻。12名患者在基线评估后的6个月内死亡,死亡率为57.1%:结论:同时感染肺结核和组织胞浆菌病的艾滋病病毒感染者主要表现为播散型感染,症状和体征不明确。这些证据要求及早筛查艾滋病病毒和机会性感染,并深入了解对同时感染组织胞浆菌病和肺结核的艾滋病病毒感染者进行有效诊断和治疗所面临的挑战和机遇。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Clinical characteristics, diagnosis, treatment and outcomes of patients living with HIV and co-infected with tuberculosis and histoplasmosis: a 5-y retrospective case series.

Background: In Latin America, tuberculosis (TB) and histoplasmosis are two of the most frequent opportunistic infections affecting people living with human immunodeficiency virus (HIV). However, there are limited data on the clinical characteristics and outcomes of patients with concurrent TB and histoplasmosis infections.

Methods: This was a retrospective observational study to describe the clinical, epidemiological and laboratory characteristics and outcomes of 21 patients living with HIV (PLHIV) who were diagnosed with concurrent histoplasmosis and TB between 2017 and 2021 in Guatemala City, Guatemala.

Results: Most patients were male and were newly diagnosed with HIV. All patients had advanced HIV disease (AHD). They presented with a median CD4 count of 20 cells/µl. The most common symptoms reported by the patients were fever, weight loss, cough and diarrhoea. Twelve patients died within 6 months of baseline evaluation, for a mortality rate of 57.1%.

Conclusions: PLHIV with concurrent TB and histoplasmosis infections are characterised by AHD, predominantly presenting with disseminated forms of these infections and with unspecific symptoms and signs. This evidence calls for early HIV and opportunistic infection screening and insights into the challenges and opportunities for the efficient diagnostic and therapeutic management of patients with AHD with concurrent histoplasmosis and TB infections.

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来源期刊
Transactions of The Royal Society of Tropical Medicine and Hygiene
Transactions of The Royal Society of Tropical Medicine and Hygiene 医学-公共卫生、环境卫生与职业卫生
CiteScore
4.00
自引率
9.10%
发文量
115
审稿时长
4-8 weeks
期刊介绍: Transactions of the Royal Society of Tropical Medicine and Hygiene publishes authoritative and impactful original, peer-reviewed articles and reviews on all aspects of tropical medicine.
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