食用疫苗:专利驱动的免疫技术探索。

Q3 Biochemistry, Genetics and Molecular Biology
Sahil Kashyap, Shikha Kamboj, Rohit Kamboj, Kumar Guarve, Sweta Kamboj
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引用次数: 0

摘要

疫苗是一种生物制剂,可提高对特定疾病的免疫力。特别是对于贫穷的发展中国家来说,可食用疫苗作为一种经济上有利、管理简单、易于储存、安全可靠以及社会和文化上可接受的疫苗输送系统,显示出巨大的潜力。疫苗将编码细菌或病毒致病因子的基因植入植物中,而不会失去其免疫原性。马铃薯、西红柿、大米、大豆和香蕉是可食用疫苗的主要植物。它能激活全身和粘膜免疫反应,抵御外来致病生物。它为减少乙型肝炎、狂犬病、艾滋病毒/艾滋病(人类免疫缺陷病毒感染和获得性免疫缺陷综合征)等疾病提供了令人兴奋的可能性。这些疫苗有很多好处,比如方便接种、有效储存,以及适合不同年龄段患者的给药系统。因此,可食用疫苗可能是提高免疫力最方便的疫苗。然而,在可食用疫苗技术的发展道路上,还有许多技术和监管方面的挑战需要克服。尽管所有这些似乎都可以克服,但各种技术障碍以及监管和非科学挑战仍需克服。此外,可食用疫苗专利代表了生物技术的一个前沿领域,将遗传物质融入可食用物质有望彻底改变疫苗接种方法。这些专利旨在利用植物和其他可食用物质的潜力来刺激免疫反应,为传统注射疫苗提供潜在的替代方案。本综述介绍了可食用疫苗的技术、宿主植物、现状、最新专利、这一新型预防方式的未来,以及与可食用疫苗有关的各种监管问题。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Edible Vaccines: A Patent-Driven Exploration of Immunization Technologies.

Vaccines are biological preparations that improve immunity to particular diseases. Particularly for poor developing nations, edible vaccines show significant potential as a financially advantageous, simple to administer, straightforward to store, fail-safe, and socially and culturally acceptable vaccine delivery system. A vaccine incorporates the gene-encoding bacterial or viral disease-causing agent in plants without losing its immunogenic property. Potatoes, tomatoes, rice, soybeans, and bananas are the primary plants for edible vaccines. It activates the systemic and mucosal immunity responses against a foreign disease-causing organism. It offers exciting possibilities to reduce diseases like hepatitis B, rabies, HIV/AIDS (human immunodeficiency virus infection and acquired immune deficiency syndrome), etc. These vaccines provide many benefits, like being convenient to administer, efficiently storing, and readily acceptable drug delivery systems for patients of different age groups. So, an edible vaccine may be the most convenient vaccine to improve immunity. However, there are a lot of technical and regulatory challenges to overcome in the way of edible vaccine technology. Though all seem surmountable, various technical obstacles and regulatory and non-scientific challenges need to be overcome. Moreover, edible vaccine patents represent a cutting-edge area of biotechnology, where the integration of genetic material into edible substances holds great promise for revolutionizing vaccination methods. These patents aim to harness the potential of plants and other edibles to stimulate immune responses, offering a potential alternative to traditional injectable vaccines. This review states the technologies, host plants, current status, recent patents, the future of this new preventive modality, and different regulatory issues concerning edible vaccines.

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来源期刊
Recent patents on biotechnology
Recent patents on biotechnology Biochemistry, Genetics and Molecular Biology-Biotechnology
CiteScore
2.90
自引率
0.00%
发文量
51
期刊介绍: Recent Patents on Biotechnology publishes review articles by experts on recent patents on biotechnology. A selection of important and recent patents on biotechnology is also included in the journal. The journal is essential reading for all researchers involved in all fields of biotechnology.
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