皮肤和软组织感染的新治疗方案,根据患者的具体情况选择药物。

IF 3.6 3区 医学 Q2 INFECTIOUS DISEASES
Current Opinion in Infectious Diseases Pub Date : 2024-04-01 Epub Date: 2024-01-24 DOI:10.1097/QCO.0000000000001003
Nadia Castaldo, Antonio Vena, Alessandro Limongelli, Daniele Roberto Giacobbe, Matteo Bassetti
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引用次数: 0

摘要

综述的目的:简要概述处于II期和III期研发阶段的治疗急性细菌性皮肤和皮肤结构感染(ABSSSI)的药物,为潜在的定制治疗方案提供见解:目前有几种治疗 ABSSSI 的药物正处于后期评估阶段,还有许多分子正处于早期开发阶段。摘要:根据患者特征、可能的病原体、ABSSSI 的类型、部位和严重程度来定制抗生素疗法至关重要。鉴于现有治疗方法的固有局限性,开发新型药物是一个关键途径。在日常临床实践中,这些进展有望提高治疗效果并简化 ABSSSI 的药物选择。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Emerging treatment options for skin and soft tissue infections tailoring drug selection to individual patients.

Purpose of review: To provide a brief overview of drugs in Phase II and III of development for the treatment of acute bacterial skin and skin structure infections (ABSSSI), offering insights into potential customized treatment options.

Recent findings: Several drugs are currently in advanced stages of evaluation for the treatment of ABSSSI, and numerous molecules are entering in the early development phases. Notably, many of these drugs exhibit unique mechanisms of action and interesting antimicrobial spectrum.

Summary: Tailoring antibiotic therapy based on patient characteristics, likely pathogens, type, site and severity of ABSSSI is crucial. Given the inherent limitations of available treatments, the development of novel agents is a pivotal avenue. Such advancements hold promise for enhancing treatment efficacy and simplifying drug selection for ABSSSI in everyday clinical practice.

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来源期刊
CiteScore
6.70
自引率
2.60%
发文量
121
审稿时长
6-12 weeks
期刊介绍: This reader-friendly, bimonthly resource provides a powerful, broad-based perspective on the most important advances from throughout the world literature. Featuring renowned guest editors and focusing exclusively on two topics, every issue of Current Opinion in Infectious Disease delivers unvarnished, expert assessments of developments from the previous year. Insightful editorials and on-the-mark invited reviews cover key subjects such as HIV infection and AIDS; skin and soft tissue infections; respiratory infections; paediatric and neonatal infections; gastrointestinal infections; tropical and travel-associated diseases; and antimicrobial agents.
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