病毒感染与肝病的交集:全面回顾发病机制、诊断和治疗。

IF 4.6 3区 医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL
WIREs Mechanisms of Disease Pub Date : 2024-05-01 Epub Date: 2024-01-22 DOI:10.1002/wsbm.1640
Meng Ren, Chenxia Lu, Mingwei Zhou, Xiaobing Jiang, Xiaodong Li, Ningning Liu
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引用次数: 0

摘要

肝脏疾病是全球的一个重大负担,它使人们面临罹患肝硬化和肝癌的更高风险。在全球范围内,病毒感染是导致肝病的主要原因。虽然丙型肝炎病毒(HCV)可以通过抗病毒药物有效治愈,但目前还没有开发出预防性疫苗,因此,肝炎病毒(尤其是乙型、丙型和戊型肝炎病毒)感染是造成急性和慢性肝内不良后果的最主要因素。乙型肝炎病毒(HBV)和丙型肝炎病毒(HCV)可导致急性和慢性肝病,包括肝硬化和肝细胞癌(HCC),它们是全球发病率和死亡率的主要原因。其他病毒,如 Epstein-Barr 病毒 (EBV) 和巨细胞病毒 (CMV),也能造成肝损伤。因此,必须认识到病毒感染和肝脏疾病是错综复杂、相互关联的过程。深刻理解病毒感染与肝脏疾病之间的内在关系,对于有效预防、诊断和治疗这些疾病至关重要。在这篇综述中,我们将深入探讨病毒感染诱发肝病的机制,并探讨肝病的发病机制、诊断和治疗。本文归类于传染病 > 生物医学工程。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The intersection of virus infection and liver disease: A comprehensive review of pathogenesis, diagnosis, and treatment.

Liver disease represents a significant global burden, placing individuals at a heightened risk of developing cirrhosis and liver cancer. Viral infections act as a primary cause of liver diseases on a worldwide scale. Infections involving hepatitis viruses, notably hepatitis B, C, and E viruses, stand out as the most prevalent contributors to acute and chronic intrahepatic adverse outcome, although the hepatitis C virus (HCV) can be effectively cured with antiviral drugs, but no preventative vaccination developed. Hepatitis B virus (HBV) and HCV can lead to both acute and chronic liver diseases, including liver cirrhosis and hepatocellular carcinoma (HCC), which are principal causes of worldwide morbidity and mortality. Other viruses, such as Epstein-Barr virus (EBV) and cytomegalovirus (CMV), are capable of causing liver damage. Therefore, it is essential to recognize that virus infections and liver diseases are intricate and interconnected processes. A profound understanding of the underlying relationship between virus infections and liver diseases proves pivotal in the effective prevention, diagnosis, and treatment of these conditions. In this review, we delve into the mechanisms by which virus infections induce liver diseases, as well as explore the pathogenesis, diagnosis, and treatment of liver diseases. This article is categorized under: Infectious Diseases > Biomedical Engineering.

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来源期刊
WIREs Mechanisms of Disease
WIREs Mechanisms of Disease MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
11.40
自引率
0.00%
发文量
45
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