六价铬对线粒体的影响及其在致癌过程中的意义。

IF 1.2 4区 环境科学与生态学 Q4 ENVIRONMENTAL SCIENCES
Anish Alur, John Phillips, Dazhong Xu
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引用次数: 0

摘要

六价铬(Cr(VI))是一种众所周知的职业和环境致癌物质。由于六价铬能够调节多个细胞靶点,因此它对细胞的影响非常复杂,而且往往是非特异性的。六价铬的毒性与其还原过程中产生的活性氧(ROS)密切相关。ROS 可导致蛋白质、脂质和 DNA 等细胞大分子氧化,从而改变它们的功能。六价铬的一个主要致癌基因毒性作用是形成 DNA 加合物,从而导致 DNA 损伤。细胞信号传导途径和表观遗传学的改变也可能导致六价铬的致癌作用。六价铬对线粒体生物学的许多方面都有重大影响,包括氧化磷酸化、有丝分裂和线粒体生物生成。这些影响有可能改变六价铬诱导的致癌过程的轨迹。这篇透视文章总结了目前人们对六价铬对线粒体影响的认识,并讨论了这一领域未来的研究方向,特别是在致癌方面。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effects of hexavalent chromium on mitochondria and their implications in carcinogenesis.

Hexavalent chromium (Cr(VI)) is a well-known occupational and environmental human carcinogen. The cellular effect of Cr(VI) is complex and often nonspecific due to its ability to modulate multiple cellular targets. The toxicity of Cr(VI) is strongly linked to the generation of reactive oxygen species (ROS) during its reduction process. ROS can cause oxidation of cellular macromolecules, such as proteins, lipids, and DNA, thereby altering their functions. A major genotoxic effect of Cr(VI) that contributes to carcinogenesis is the formation of DNA adducts, which can lead to DNA damage. Modulations of cellular signaling pathways and epigenetics may also contribute to the carcinogenic effects of Cr(VI). Cr(VI) has a major impact on many aspects of mitochondrial biology, including oxidative phosphorylation, mitophagy, and mitochondrial biogenesis. These effects have the potential to alter the trajectory of Cr(VI)-induced carcinogenic process. This perspective article summarizes current understandings of the effect of Cr(VI) on mitochondria and discusses the future directions of research in this area, particularly with regard to carcinogenesis.

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CiteScore
4.60
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