X 连锁低磷血症、成纤维细胞生长因子 23 信号传导和颅骨发育不良。

IF 2.8 4区医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL

Experimental Biology and Medicine Pub Date : 2023-11-01 Epub Date: 2024-01-17 DOI:10.1177/15353702231222023

Chelsey Grimbly, Daniel Graf, Leanne M Ward, R Todd Alexander

{"title":"X 连锁低磷血症、成纤维细胞生长因子 23 信号传导和颅骨发育不良。","authors":"Chelsey Grimbly, Daniel Graf, Leanne M Ward, R Todd Alexander","doi":"10.1177/15353702231222023","DOIUrl":null,"url":null,"abstract":"This review summarizes the current knowledge of fibroblast growth factor 23 signaling in bone and its role in the disease pathology of X-linked hypophosphatemia. Craniosynostosis is an under-recognized complication of X-linked hypophosphatemia. The clinical implications and potential cellular mechanisms invoked by increased fibroblast growth factor 23 signaling causing craniosynostosis are reviewed. Knowledge gaps are identified and provide direction for future clinical and basic science studies.","PeriodicalId":12163,"journal":{"name":"Experimental Biology and Medicine","volume":null,"pages":null},"PeriodicalIF":2.8000,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10800125/pdf/","citationCount":"0","resultStr":"{\"title\":\"X-linked hypophosphatemia, fibroblast growth factor 23 signaling, and craniosynostosis.\",\"authors\":\"Chelsey Grimbly, Daniel Graf, Leanne M Ward, R Todd Alexander\",\"doi\":\"10.1177/15353702231222023\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"This review summarizes the current knowledge of fibroblast growth factor 23 signaling in bone and its role in the disease pathology of X-linked hypophosphatemia. Craniosynostosis is an under-recognized complication of X-linked hypophosphatemia. The clinical implications and potential cellular mechanisms invoked by increased fibroblast growth factor 23 signaling causing craniosynostosis are reviewed. Knowledge gaps are identified and provide direction for future clinical and basic science studies.\",\"PeriodicalId\":12163,\"journal\":{\"name\":\"Experimental Biology and Medicine\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.8000,\"publicationDate\":\"2023-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10800125/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Experimental Biology and Medicine\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1177/15353702231222023\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/1/17 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"MEDICINE, RESEARCH & EXPERIMENTAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Experimental Biology and Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/15353702231222023","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/17 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}

引用次数: 0

摘要

本综述总结了目前关于成纤维细胞生长因子23在骨骼中的信号转导及其在X连锁性低磷血症病理中的作用的知识。颅骨发育不良是X连锁低磷血症的一种未被充分认识的并发症。本文综述了成纤维细胞生长因子 23 信号传导增加导致颅骨发育不良的临床影响和潜在细胞机制。指出了知识空白，并为未来的临床和基础科学研究提供了方向。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

X-linked hypophosphatemia, fibroblast growth factor 23 signaling, and craniosynostosis.

This review summarizes the current knowledge of fibroblast growth factor 23 signaling in bone and its role in the disease pathology of X-linked hypophosphatemia. Craniosynostosis is an under-recognized complication of X-linked hypophosphatemia. The clinical implications and potential cellular mechanisms invoked by increased fibroblast growth factor 23 signaling causing craniosynostosis are reviewed. Knowledge gaps are identified and provide direction for future clinical and basic science studies.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Experimental Biology and Medicine 医学-医学：研究与实验

CiteScore

6.00

自引率

0.00%

发文量

157

审稿时长

1 months

期刊介绍： Experimental Biology and Medicine (EBM) is a global, peer-reviewed journal dedicated to the publication of multidisciplinary and interdisciplinary research in the biomedical sciences. EBM provides both research and review articles as well as meeting symposia and brief communications. Articles in EBM represent cutting edge research at the overlapping junctions of the biological, physical and engineering sciences that impact upon the health and welfare of the world''s population. Topics covered in EBM include: Anatomy/Pathology; Biochemistry and Molecular Biology; Bioimaging; Biomedical Engineering; Bionanoscience; Cell and Developmental Biology; Endocrinology and Nutrition; Environmental Health/Biomarkers/Precision Medicine; Genomics, Proteomics, and Bioinformatics; Immunology/Microbiology/Virology; Mechanisms of Aging; Neuroscience; Pharmacology and Toxicology; Physiology; Stem Cell Biology; Structural Biology; Systems Biology and Microphysiological Systems; and Translational Research.