印度低风险孕妇的早产预测:宫颈长度、血清铁蛋白和血清甲胎蛋白的鉴别力。

IF 0.8 Q3 MEDICINE, GENERAL & INTERNAL
Lakavath Jyothi, Mousumi Datta, Divyangana Mitra, Jhuma Biswas, Arghya Maitra, Kaushik Kar
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引用次数: 0

摘要

背景:约80%的早产(PTBs)是自然发生的。目的:本研究旨在确定血清生物标志物(铁蛋白和甲胎蛋白(AFP)在孕中期的临界值)和宫颈长度(CL)评估的准确性,以预测低风险孕妇的早产情况:方法:纳入 300 名在一家三级医疗保健机构产前门诊就诊的低危孕妇,在孕中期通过经阴道超声波检查测量宫颈长度,并记录她们的血清铁蛋白和甲胎蛋白水平。结果结果:构建了铁蛋白、甲胎蛋白和CL的受体操作特征曲线。结果:构建了铁蛋白、甲胎蛋白和 CL 的受体作用特征曲线,计算出的每种标记物的曲线下面积和尤登指数都很低(结论:铁蛋白和甲胎蛋白的受体作用特征曲线都很低,而 CL 的受体作用特征曲线则很高:妊娠后三个月的血清铁蛋白、甲胎蛋白和 CL 测量在预测低风险无症状孕妇早产方面的鉴别价值很低。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Prediction of Preterm Delivery among Low-risk Indian Pregnant Women: Discriminatory Power of Cervical Length, Serum Ferritin, and Serum Alpha-fetoprotein.

Background: Around 80% of preterm births (PTBs) occur spontaneously. Various biomarkers are being evaluated to assess the possible role of chorioamniotic inflammation in PTBs.

Aim: The aim of this study was to establish the accuracy of serum bio-markers( cut off values of ferritin and alpha-fetoprotein [AFP] at midtrimester) along with cervical length [CL] assessment to predict preterm delivery among low-risk women.

Methods: Three hundred low-risk pregnant women attending the antenatal clinic of a tertiary health care facility were included and underwent CL measurement during mid-trimester by transvaginal ultrasonography and their serum levels of ferritin and AFP were recorded. All were followed up till delivery.

Results: Receptor-operated characteristic curves for ferritin, AFP, and CL were constructed. Area under curves and Youden Index calculated for each marker were very low (<0.5) which is statistically considered very poor for a screening test.

Conclusion: Serum ferritin and AFP together with CL measurement in the second trimester of pregnancy had poor discriminatory value in predicting preterm delivery among low-risk asymptomatic pregnant women.

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