低氧诱导因子 1 的调节机制及其临床意义

IF 2.4 4区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Current molecular pharmacology Pub Date : 2024-01-15 DOI:10.2174/0118761429266116231123160809

Chun-Li Yin, Yu-Jie Ma

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引用次数: 0

摘要

::缺氧诱导因子（HIF）是一种核蛋白，通过其转录活性和数千个靶基因谱在氧平衡中发挥着至关重要的作用。通过转录和转录后调控，HIF 的下游靶基因可引发机体的多种病理反应，包括能量代谢、细胞减少和血管生成。HIF 有三种不同的亚型：HIF-1、HIF-2 和 HIF-3。HIF-1 是细胞对缺氧反应的重要调节因子，其产生和降解之间的平衡对这种反应至关重要。由于缺氧与多种疾病相关，了解 HIF 可以为治疗多种疾病开辟新的途径。本综述介绍了 HIF-1 合成和降解的调控机制，以及缺氧诱导因子通路在肺损伤、肾脏疾病、血液病和炎症相关疾病中的临床意义。

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The Regulatory Mechanism of Hypoxia-inducible Factor 1 and its Clinical Significance

:: Hypoxia-inducible factor (HIF) is a nuclear protein that plays a crucial role in oxygen homeostasis through its transcriptional activity and thousands of target gene profiles. Through transcriptional and post-transcriptional regulation, the downstream target genes of HIF can trigger multiple pathological responses in the body, including energy metabolism, cytopenia, and angiogenesis. There are three distinct subtypes of HIF: HIF-1, HIF-2, and HIF-3. HIF-1 is a significant regulator of the cellular response to hypoxia, and the balance between its production and degradation is critical for this response. As hypoxia is linked to several disorders, understanding HIF can open up novel avenues for the treatment of many diseases. This review describes the regulatory mechanisms of HIF-1 synthesis and degradation and the clinical significance of the hypoxia-inducible factor pathway in lung injury, kidney disease, hematologic disorders, and inflammation-related diseases.

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来源期刊

Current molecular pharmacology Pharmacology, Toxicology and Pharmaceutics-Drug Discovery

CiteScore

4.90

自引率

3.70%

发文量

112

期刊介绍： Current Molecular Pharmacology aims to publish the latest developments in cellular and molecular pharmacology with a major emphasis on the mechanism of action of novel drugs under development, innovative pharmacological technologies, cell signaling, transduction pathway analysis, genomics, proteomics, and metabonomics applications to drug action. An additional focus will be the way in which normal biological function is illuminated by knowledge of the action of drugs at the cellular and molecular level. The journal publishes full-length/mini reviews, original research articles and thematic issues on molecular pharmacology. Current Molecular Pharmacology is an essential journal for every scientist who is involved in drug design and discovery, target identification, target validation, preclinical and clinical development of drugs therapeutically useful in human disease.