Bassem Al Hariri , Rawan S. Mohamed , Hadil Altaj Altrify Alsidig , Abdulqadir J. Nashwan , Muad Abdi Hassan
{"title":"一名年轻成人罕见的胃肠道间质瘤(GIST)病例","authors":"Bassem Al Hariri , Rawan S. Mohamed , Hadil Altaj Altrify Alsidig , Abdulqadir J. Nashwan , Muad Abdi Hassan","doi":"10.1016/j.hmedic.2024.100040","DOIUrl":null,"url":null,"abstract":"<div><p>Gastrointestinal stromal tumors (GISTs) are common primary mesenchymal neoplasms in the gastrointestinal tract. Although they account for less than 1 % of all GI tumors, high-risk or cancerous GISTs make up 20 % to 30 % of all cases. GISTs mostly affect people over 50 years old, with symptoms including bowel obstruction, constipation, GI bleeding, dysphagia, jaundice, and urination problems in males. KIT is highly expressed in GISTs, but tyrosine kinase inhibitors (TKI) such as imatinib, sunitinib, regorafenib, and ripretinib can target these tumors effectively. The therapy of GIST metastases in the liver is controversial, and metastatic liver disease is a significant factor in determining patient survival. Early detection and timely treatment can significantly improve the patient's prognosis and increase their chances of survival.</p></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"3 ","pages":"Article 100040"},"PeriodicalIF":0.0000,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949918624000056/pdfft?md5=ec2376bac0bdec3156512aae0db3abe6&pid=1-s2.0-S2949918624000056-main.pdf","citationCount":"0","resultStr":"{\"title\":\"A rare case presentation of gastrointestinal stromal tumor (GIST) in a young adult patient\",\"authors\":\"Bassem Al Hariri , Rawan S. Mohamed , Hadil Altaj Altrify Alsidig , Abdulqadir J. Nashwan , Muad Abdi Hassan\",\"doi\":\"10.1016/j.hmedic.2024.100040\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Gastrointestinal stromal tumors (GISTs) are common primary mesenchymal neoplasms in the gastrointestinal tract. Although they account for less than 1 % of all GI tumors, high-risk or cancerous GISTs make up 20 % to 30 % of all cases. GISTs mostly affect people over 50 years old, with symptoms including bowel obstruction, constipation, GI bleeding, dysphagia, jaundice, and urination problems in males. KIT is highly expressed in GISTs, but tyrosine kinase inhibitors (TKI) such as imatinib, sunitinib, regorafenib, and ripretinib can target these tumors effectively. The therapy of GIST metastases in the liver is controversial, and metastatic liver disease is a significant factor in determining patient survival. Early detection and timely treatment can significantly improve the patient's prognosis and increase their chances of survival.</p></div>\",\"PeriodicalId\":100908,\"journal\":{\"name\":\"Medical Reports\",\"volume\":\"3 \",\"pages\":\"Article 100040\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-01-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S2949918624000056/pdfft?md5=ec2376bac0bdec3156512aae0db3abe6&pid=1-s2.0-S2949918624000056-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Medical Reports\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2949918624000056\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Medical Reports","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2949918624000056","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
A rare case presentation of gastrointestinal stromal tumor (GIST) in a young adult patient
Gastrointestinal stromal tumors (GISTs) are common primary mesenchymal neoplasms in the gastrointestinal tract. Although they account for less than 1 % of all GI tumors, high-risk or cancerous GISTs make up 20 % to 30 % of all cases. GISTs mostly affect people over 50 years old, with symptoms including bowel obstruction, constipation, GI bleeding, dysphagia, jaundice, and urination problems in males. KIT is highly expressed in GISTs, but tyrosine kinase inhibitors (TKI) such as imatinib, sunitinib, regorafenib, and ripretinib can target these tumors effectively. The therapy of GIST metastases in the liver is controversial, and metastatic liver disease is a significant factor in determining patient survival. Early detection and timely treatment can significantly improve the patient's prognosis and increase their chances of survival.