一名年轻成人罕见的胃肠道间质瘤(GIST)病例

Bassem Al Hariri , Rawan S. Mohamed , Hadil Altaj Altrify Alsidig , Abdulqadir J. Nashwan , Muad Abdi Hassan
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引用次数: 0

摘要

胃肠道间质瘤(GIST)是胃肠道常见的原发性间叶肿瘤。虽然它们在所有胃肠道肿瘤中所占比例不到 1%,但高危或癌症 GIST 占所有病例的 20% 至 30%。GIST 大多影响 50 岁以上的人群,症状包括肠梗阻、便秘、消化道出血、吞咽困难、黄疸和男性排尿困难。KIT 在 GIST 中高度表达,但伊马替尼、舒尼替尼、瑞戈非尼和瑞普替尼等酪氨酸激酶抑制剂(TKI)可有效针对这些肿瘤。对肝脏中 GIST 转移灶的治疗存在争议,转移性肝病是决定患者生存期的重要因素。早期发现和及时治疗可以明显改善患者的预后,增加其生存机会。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A rare case presentation of gastrointestinal stromal tumor (GIST) in a young adult patient

Gastrointestinal stromal tumors (GISTs) are common primary mesenchymal neoplasms in the gastrointestinal tract. Although they account for less than 1 % of all GI tumors, high-risk or cancerous GISTs make up 20 % to 30 % of all cases. GISTs mostly affect people over 50 years old, with symptoms including bowel obstruction, constipation, GI bleeding, dysphagia, jaundice, and urination problems in males. KIT is highly expressed in GISTs, but tyrosine kinase inhibitors (TKI) such as imatinib, sunitinib, regorafenib, and ripretinib can target these tumors effectively. The therapy of GIST metastases in the liver is controversial, and metastatic liver disease is a significant factor in determining patient survival. Early detection and timely treatment can significantly improve the patient's prognosis and increase their chances of survival.

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