TNF-α 308 G/A (rs1800629) 基因多态性与伊拉克重型地中海贫血成人的肝脏和胰腺疾病有关吗？

Q3 Medicine

Human Antibodies Pub Date : 2023-01-01 DOI:10.3233/HAB-230015

Hawraa Allawi Luaibi, Bushra Jasim Mohammed

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引用次数: 0

摘要

背景：TNF-α 被认为是炎症反应的关键调节因子，已知参与了多种疾病的发病机制：本研究旨在探讨重型β地中海贫血症成年伊拉克患者样本中（rs1800629）基因多态性与肝脏和胰腺疾病的关系：从巴格达 Ibn Al-Baladi 医院的 40 名患有胰腺疾病的β地中海贫血症患者、40 名患有肝脏疾病的地中海贫血症患者和 40 名患有无胰腺或肝脏疾病的地中海贫血症患者中采集血样，并从年龄和性别相匹配的表面健康人中采集 40 份血样作为对照组，所有受试者的年龄均超过 18 岁。通过 Tetra- ARMS-PCR 对 TNF-308G/A (rs1800629) 基因多态性进行了评估：结果显示，与对照组相比，患有肝脏和胰腺疾病的重型地中海贫血患者的异质性 GA 和同质性 AA 基因型较高，而 GG 野生基因型较低：结论：在重型地中海贫血成人样本中，TNF-α 308 G/A SNP 加（A）等位基因的患病率可能与肝脏和胰腺疾病的风险有关。

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Does TNF-α 308 G/A (rs1800629) gene polymorphism associate with liver and pancreas disorders in Iraqi adults with beta thalassemia major?

Background: TNF-α has been considered as the key regulator of inflammatory responses and is known to be participated in the pathogenesis of several diseases.

Objective: The aim of this study was to explore the relationship of (rs1800629) gene polymorphism associated to liver and pancreas disorders in sample of β-thalassemia major adult Iraqi Patients.

Material and method: Blood samples were obtained from 40 patients suffered from beta thalassemia with pancreas disorder, along with 40 patient suffered from thalassemia with liver disorder, and 40 patient suffered from thalassemia without pancreas or liver, from Ibn Al-Baladi Hospital, Baghdad, and 40 samples from age and gender-matched apparently healthy individuals as control group, all subjects with age more than 18 years. TNF-308G/A (rs1800629) gene polymorphisms were assessed by Tetra- ARMS-PCR.

Results: The result of showed that heterogeneous GA and homogeneous AA genotypes were higher, while GG wild genotype was lower in beta thalassemia major patients with liver and pancreas disorders compared to control group.

Conclusion: It can be concluded that the prevalence of TNF-α 308 G/A SNP plus (A) allele could be associated with risk of liver and pancreas disorders in sample of beta thalassemia major adult.

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来源期刊

Human Antibodies Medicine-Immunology and Allergy

CiteScore

3.50

自引率

0.00%

发文量

期刊介绍： Human Antibodies is an international journal designed to bring together all aspects of human hybridomas and antibody technology under a single, cohesive theme. This includes fundamental research, applied science and clinical applications. Emphasis in the published articles is on antisera, monoclonal antibodies, fusion partners, EBV transformation, transfections, in vitro immunization, defined antigens, tissue reactivity, scale-up production, chimeric antibodies, autoimmunity, natural antibodies/immune response, anti-idiotypes, and hybridomas secreting interesting growth factors. Immunoregulatory molecules, including T cell hybridomas, will also be featured.