欧加木乙醇提取物的气相色谱-质谱分析：网络药理学分析对肥胖症的启示

IF 2.4 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Future Science OA Pub Date : 2024-01-10 DOI:10.2144/fsoa-2023-0202

Priyadharshini Gnanamurthy, Manoj K Narasimhan, Sarvesh Sabarathinam

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引用次数: 0

摘要

目的：在本研究中，我们选择了两种不同的 Ocimum tenuiflorum 植物：Ocimum tenuiflorum（Rama tulsi）（OTRT）和 Ocimum tenuiflorum（Krishna tulsi）（OTKT）。材料与方法：本研究使用乙醇作为溶剂，通过气相色谱-质谱法（GC-MS）估测其中的生物活性化合物。结果：根据气相色谱-质谱数据，发现 OTRT（截留分子量：428.74 克/摩尔）和 OTKT（截留分子量：342.39 克/摩尔）中的 3-(4-苄氧基-3,5-二甲氧基苯基)-2-甲基丙酸甲酯是苯丙酸、3-甲氧基-α,4-双[（三甲基硅基）氧基]的有效化合物。为了评估其药理应用，我们针对肥胖症这一疾病目标，采用了一种综合网络药理学方法。结论从字符串数据库中的蛋白质-蛋白质相互作用来看，SRC、BCL2、表皮生长因子受体、MTOR、CDK1、ERBB2、MAPK1、FYN、AR 和 MAPK14 是排名靠前的靶点。

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GC-MS analysis of an ethanolic extract of Ocimum species: a network pharmacology analysis insight towards obesity

Aim: In this study, we have selected two different Ocimum tenuiflorum plants, Ocimum tenuiflorum (Rama tulsi) (OTRT) and Ocimum tenuiflorum (Krishna tulsi) (OTKT). Materials & methods: In the present investigation, ethanol was used as a solvent to estimate the bioactive compounds present in it through gas chromatography-mass spectrometry (GC–MS). Results: Based on the GC-MS data benzenepropanoic acid, 3-methoxy-alpha,4-bis[(trimethylsilyl)oxy was found to be the potent compound in OTRT (MW:428.74 g/mol) and methyl 3-(4-benzyloxy-3,5-dimethoxyphenyl)-2-methylpropanoate in OTKT (MW:342.39 g/mol). To estimate its pharmacological application, an integrated Network Pharmacology approach is performed toward the disease target obesity. Conclusion: From the Protein–Protein interaction from the string database, SRC, BCL2, EGFR, MTOR, CDK1, ERBB2, MAPK1, FYN, AR and MAPK14 are the top-ranked targets.

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来源期刊

Future Science OA MEDICINE, RESEARCH & EXPERIMENTAL-

CiteScore

5.00

自引率

4.00%

发文量

审稿时长

13 weeks

期刊介绍： Future Science OA is an online, open access, peer-reviewed title from the Future Science Group. The journal covers research and discussion related to advances in biotechnology, medicine and health. The journal embraces the importance of publishing all good-quality research with the potential to further the progress of research in these fields. All original research articles will be considered that are within the journal''s scope, and have been conducted with scientific rigour and research integrity. The journal also features review articles, editorials and perspectives, providing readers with a leading source of commentary and analysis. Submissions of the following article types will be considered: -Research articles -Preliminary communications -Short communications -Methodologies -Trial design articles -Trial results (including early-phase and negative studies) -Reviews -Perspectives -Commentaries