探索生物碱在阿尔茨海默病治疗中的治疗潜力。

Randhir Singh, Nidhi Rani, Rajwinder Kaur, Geeta Chahal, Praveen Kumar, Gagandeep Kaur
{"title":"探索生物碱在阿尔茨海默病治疗中的治疗潜力。","authors":"Randhir Singh, Nidhi Rani, Rajwinder Kaur, Geeta Chahal, Praveen Kumar, Gagandeep Kaur","doi":"10.2174/0118715249269092231109181638","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Alkaloids are important phytoconstituents obtained from various plant sources. The study's primary goal is to assess the anti-Alzheimer potential of alkaloids using a molecular docking study. Alzheimer's disease (AD) is considered a gradual decline in memory, reasoning, decision-making, orientation to one's physical surroundings, and language.</p><p><strong>Materials and methods: </strong>The main target i.e. acetylcholinesterase proteins was selected for the molecular docking study.</p><p><strong>Results: </strong>The structures of various alkaloids were drawn using Chem Draw Software, PDB was retrieved from the RCSB PDB database, and molecular docking study was performed on Molergo Virtual Docker. The potential alkaloids were identified with anti-Alzheimer potency.</p><p><strong>Conclusion: </strong>Reserpine, vinblastine, ergotamine, and tubocurarine were found to exhibit potential anti-Alzheimer potency.</p>","PeriodicalId":93930,"journal":{"name":"Central nervous system agents in medicinal chemistry","volume":" ","pages":"206-218"},"PeriodicalIF":0.0000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Exploring the Therapeutic Potential of Alkaloids in Alzheimer's Disease Management.\",\"authors\":\"Randhir Singh, Nidhi Rani, Rajwinder Kaur, Geeta Chahal, Praveen Kumar, Gagandeep Kaur\",\"doi\":\"10.2174/0118715249269092231109181638\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Alkaloids are important phytoconstituents obtained from various plant sources. The study's primary goal is to assess the anti-Alzheimer potential of alkaloids using a molecular docking study. Alzheimer's disease (AD) is considered a gradual decline in memory, reasoning, decision-making, orientation to one's physical surroundings, and language.</p><p><strong>Materials and methods: </strong>The main target i.e. acetylcholinesterase proteins was selected for the molecular docking study.</p><p><strong>Results: </strong>The structures of various alkaloids were drawn using Chem Draw Software, PDB was retrieved from the RCSB PDB database, and molecular docking study was performed on Molergo Virtual Docker. The potential alkaloids were identified with anti-Alzheimer potency.</p><p><strong>Conclusion: </strong>Reserpine, vinblastine, ergotamine, and tubocurarine were found to exhibit potential anti-Alzheimer potency.</p>\",\"PeriodicalId\":93930,\"journal\":{\"name\":\"Central nervous system agents in medicinal chemistry\",\"volume\":\" \",\"pages\":\"206-218\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Central nervous system agents in medicinal chemistry\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2174/0118715249269092231109181638\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Central nervous system agents in medicinal chemistry","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/0118715249269092231109181638","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

背景:生物碱是从各种植物中提取的重要植物成分。本研究的主要目的是通过分子对接研究评估生物碱的抗阿尔茨海默病潜力。阿尔茨海默病(AD)被认为是一种记忆力、推理能力、决策能力、对周围环境的适应能力和语言能力逐渐下降的疾病:方法和材料:选择主要靶标(即乙酰胆碱酯酶蛋白)进行分子对接研究:结果:使用 Chem Draw 软件绘制了各种生物碱的结构,从 RCSB PDB 数据库检索了 PDB,并在 Molergo Virtual Docker 上进行了分子对接研究。结果表明,这些潜在生物碱具有抗阿尔茨海默氏症的功效:结论:发现瑞香素、长春花碱、麦角胺和管果碱具有潜在的抗老年痴呆功效。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Exploring the Therapeutic Potential of Alkaloids in Alzheimer's Disease Management.

Background: Alkaloids are important phytoconstituents obtained from various plant sources. The study's primary goal is to assess the anti-Alzheimer potential of alkaloids using a molecular docking study. Alzheimer's disease (AD) is considered a gradual decline in memory, reasoning, decision-making, orientation to one's physical surroundings, and language.

Materials and methods: The main target i.e. acetylcholinesterase proteins was selected for the molecular docking study.

Results: The structures of various alkaloids were drawn using Chem Draw Software, PDB was retrieved from the RCSB PDB database, and molecular docking study was performed on Molergo Virtual Docker. The potential alkaloids were identified with anti-Alzheimer potency.

Conclusion: Reserpine, vinblastine, ergotamine, and tubocurarine were found to exhibit potential anti-Alzheimer potency.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信