灵芝子实体的新发现开创了蘑菇外消旋天然产品的新纪元。

IF 10.9 1区医学 Q1 CHEMISTRY, MEDICINAL

Medicinal Research Reviews Pub Date : 2024-01-10 DOI:10.1002/med.22006

Jiao-Jiao Zhang, Fu-Ying Qin, Yong-Xian Cheng

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引用次数: 0

摘要

迄今为止，已发现含有 688 种结构的灵芝类物质（GMs）具有多种显著的生物活性。在灵芝物种中，65.6%的具有立体源中心的经配体是外消旋体。此外，不同灵芝物种的子实体似乎各有特点。在这篇综述中，我们全面总结了 2000 年以来的 GMs，包括 GM 结构、结构校正、生物活性、理化性质、全合成和拟议的生物合成途径。此外，我们还特别讨论了基因改造物的外消旋性质、与物种相关的结构分布以及结构-活性关系，这将为我们提供一个可能的内部数据库，并为今后的基因改造物研究提供启示。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Insights into Ganoderma fungi meroterpenoids opening a new era of racemic natural products in mushrooms

Ganoderma meroterpenoids (GMs) containing 688 structures to date were discovered to have multiple remarkable biological activities. 65.6% of meroterpenoids featuring stereogenic centers from Ganoderma species are racemates. Further, GMs from different Ganoderma species seem to have their own characteristics. In this review, a comprehensive summarization of GMs since 2000 is presented, including GM structures, structure corrections, biological activities, physicochemical properties, total synthesis, and proposed biosynthetic pathways. Additionally, we especially discuss the racemic nature, species-related structural distribution, and structure–activity relationship of GMs, which will provide a likely in-house database and shed light on future studies on GMs.

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来源期刊

Medicinal Research Reviews 医学-药学

CiteScore

29.30

自引率

0.00%

发文量

审稿时长

2 months

期刊介绍： Medicinal Research Reviews is dedicated to publishing timely and critical reviews, as well as opinion-based articles, covering a broad spectrum of topics related to medicinal research. These contributions are authored by individuals who have made significant advancements in the field. Encompassing a wide range of subjects, suitable topics include, but are not limited to, the underlying pathophysiology of crucial diseases and disease vectors, therapeutic approaches for diverse medical conditions, properties of molecular targets for therapeutic agents, innovative methodologies facilitating therapy discovery, genomics and proteomics, structure-activity correlations of drug series, development of new imaging and diagnostic tools, drug metabolism, drug delivery, and comprehensive examinations of the chemical, pharmacological, pharmacokinetic, pharmacodynamic, and clinical characteristics of significant drugs.