铁突变过程中的膜动力学和阳离子处理

IF 5.3 2区 医学 Q1 PHYSIOLOGY
Physiology Pub Date : 2024-03-01 Epub Date: 2024-01-09 DOI:10.1152/physiol.00029.2023
Yusuke Hirata, Eikan Mishima
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引用次数: 0

摘要

铁中毒是一种以过度脂质过氧化为特征的调节性细胞死亡,与各种(病理)生理环境有关。在铁中毒过程中,脂质过氧化导致膜特性发生多种变化,并通过阳离子通道导致离子平衡失调,最终导致质膜破裂。这篇综述阐明了铁变态反应调节过程中的细胞膜动力学和阳离子处理。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Membrane Dynamics and Cation Handling in Ferroptosis.

Ferroptosis, a regulated cell death hallmarked by excessive lipid peroxidation, is implicated in various (patho)physiological contexts. During ferroptosis, lipid peroxidation leads to a diverse change in membrane properties and the dysregulation of ion homeostasis via the cation channels, ultimately resulting in plasma membrane rupture. This review illuminates cellular membrane dynamics and cation handling in ferroptosis regulation.

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来源期刊
Physiology
Physiology 医学-生理学
CiteScore
14.50
自引率
0.00%
发文量
37
期刊介绍: Physiology journal features meticulously crafted review articles penned by esteemed leaders in their respective fields. These articles undergo rigorous peer review and showcase the forefront of cutting-edge advances across various domains of physiology. Our Editorial Board, comprised of distinguished leaders in the broad spectrum of physiology, convenes annually to deliberate and recommend pioneering topics for review articles, as well as select the most suitable scientists to author these articles. Join us in exploring the forefront of physiological research and innovation.
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