Yi Yi , Zihui Yang , Chuchao Zhou , Yanqing Yang , Yiping Wu , Qi Zhang
{"title":"包裹槲皮素的 GelMa 水凝胶微针可降低氧化应激并促进伤口愈合","authors":"Yi Yi , Zihui Yang , Chuchao Zhou , Yanqing Yang , Yiping Wu , Qi Zhang","doi":"10.1016/j.ntm.2024.100030","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>Delayed wound healing brings additional physical, mental, and financial burdens. Microneedles (MNs) are a novel dressing form and can incorporate drug delivery systems. Quercetin is known for its remarkable antioxidant capacity and may have a distinctive effect on wound healing.</p></div><div><h3>Methods</h3><p>We designed and constructed gelatin methacryloyl (GelMa) MNs carrying Quercetin (Q-MNs). In vitro, the physical properties, cell safety, cell migration, angiogenesis, collagen formation, and oxidative stress levels, were performed to characterize Q-MNs. In vivo, the full-thickness skin wound models were established to evaluate the re-epithelialization and oxidative stress impact of the control, MN, and Q-MN groups.</p></div><div><h3>Results</h3><p>The Q-MNs were mechanically strong enough to penetrate the skin for sustained drug delivery and possessed good biocompatibility. Moreover, the Q-MNs evidently facilitated wound healing both in vitro and in vivo, and promoted collagen formation and neo-angiogenesis, and the reduction of oxidative stress levels.</p></div><div><h3>Conclusions</h3><p>The Q-MNs could motivate wound healing with enhanced collagen formation and vascularization and decreased oxidative stress levels, thus providing a feasible strategy for wound healing.</p></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"3 ","pages":"Article 100030"},"PeriodicalIF":0.0000,"publicationDate":"2024-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2790676024000013/pdfft?md5=c89128155b14ae18cb6e30a1c9431341&pid=1-s2.0-S2790676024000013-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Quercetin-encapsulated GelMa hydrogel microneedle reduces oxidative stress and facilitates wound healing\",\"authors\":\"Yi Yi , Zihui Yang , Chuchao Zhou , Yanqing Yang , Yiping Wu , Qi Zhang\",\"doi\":\"10.1016/j.ntm.2024.100030\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><p>Delayed wound healing brings additional physical, mental, and financial burdens. Microneedles (MNs) are a novel dressing form and can incorporate drug delivery systems. Quercetin is known for its remarkable antioxidant capacity and may have a distinctive effect on wound healing.</p></div><div><h3>Methods</h3><p>We designed and constructed gelatin methacryloyl (GelMa) MNs carrying Quercetin (Q-MNs). In vitro, the physical properties, cell safety, cell migration, angiogenesis, collagen formation, and oxidative stress levels, were performed to characterize Q-MNs. In vivo, the full-thickness skin wound models were established to evaluate the re-epithelialization and oxidative stress impact of the control, MN, and Q-MN groups.</p></div><div><h3>Results</h3><p>The Q-MNs were mechanically strong enough to penetrate the skin for sustained drug delivery and possessed good biocompatibility. Moreover, the Q-MNs evidently facilitated wound healing both in vitro and in vivo, and promoted collagen formation and neo-angiogenesis, and the reduction of oxidative stress levels.</p></div><div><h3>Conclusions</h3><p>The Q-MNs could motivate wound healing with enhanced collagen formation and vascularization and decreased oxidative stress levels, thus providing a feasible strategy for wound healing.</p></div>\",\"PeriodicalId\":100941,\"journal\":{\"name\":\"Nano TransMed\",\"volume\":\"3 \",\"pages\":\"Article 100030\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-01-06\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S2790676024000013/pdfft?md5=c89128155b14ae18cb6e30a1c9431341&pid=1-s2.0-S2790676024000013-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nano TransMed\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2790676024000013\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nano TransMed","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2790676024000013","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Delayed wound healing brings additional physical, mental, and financial burdens. Microneedles (MNs) are a novel dressing form and can incorporate drug delivery systems. Quercetin is known for its remarkable antioxidant capacity and may have a distinctive effect on wound healing.
Methods
We designed and constructed gelatin methacryloyl (GelMa) MNs carrying Quercetin (Q-MNs). In vitro, the physical properties, cell safety, cell migration, angiogenesis, collagen formation, and oxidative stress levels, were performed to characterize Q-MNs. In vivo, the full-thickness skin wound models were established to evaluate the re-epithelialization and oxidative stress impact of the control, MN, and Q-MN groups.
Results
The Q-MNs were mechanically strong enough to penetrate the skin for sustained drug delivery and possessed good biocompatibility. Moreover, the Q-MNs evidently facilitated wound healing both in vitro and in vivo, and promoted collagen formation and neo-angiogenesis, and the reduction of oxidative stress levels.
Conclusions
The Q-MNs could motivate wound healing with enhanced collagen formation and vascularization and decreased oxidative stress levels, thus providing a feasible strategy for wound healing.