乳腺癌保乳手术后 60 岁以上女性放弃放疗在局部复发率方面并无劣势:一项回顾性队列研究。

IF 1.3 Q4 ONCOLOGY
European journal of breast health Pub Date : 2023-12-27 eCollection Date: 2024-01-01 DOI:10.4274/ejbh.galenos.2023.2023-9-5
Anna Sachoulidou, Fani Apostolidou, Charalambos Fronis, Despoina Misailidou, Aichan Bozoglou, Themis Anastasia Tataridou, Aristomenis Ampatzoglou, Ioannis Galanis
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引用次数: 0

摘要

摘要接受保乳手术后再接受放疗的 60 岁及以上女性与接受保乳手术后不接受放疗的同龄女性的局部复发率可能没有明显差异:中位随访时间为 44 个月(四分位间距:16-82),比较了确诊乳腺癌时年龄超过 60 岁、接受保乳手术治疗且术后接受或不接受放疗的女性。主要终点是两组患者的局部复发率差异:结果:接受或不接受放疗的两组患者局部复发率无明显差异[几率比(OR)0.96,95% 置信区间(CI)0.89-1.02,费舍尔精确检验 p = 0.388],以 65 岁为分界线的两个年龄组之间也无明显差异(OR:0.99,95% CI 0.92-1.07,费舍尔精确检验 p = 0.6)。在考虑年龄分组(60-65 岁和大于 66 岁)时,局部复发率也没有差异。所有患者均接受了为期5年的激素治疗:结论:在预防局部复发方面,对选定患者不进行放疗并不比保乳手术后进行放疗差。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Omission of Radiotherapy in Women >60 Years Old After Breast Conserving Surgery for Breast Cancer is Non-Inferior in Terms of Local Recurrence: A Retrospective Cohort Study.

Objective: Local recurrence rate may show no significant differences between women aged 60 and older who receive breast-conserving surgery followed by radiotherapy and those in the same age group who undergo breast-conserving surgery without subsequent radiotherapy.

Materials and methods: Retrospective cohort study from a single practice with median follow-up time 44 months (interquartile range: 16, 82), comparing women older than 60 years old at diagnosis of breast cancer, treated with breast conserving surgery and either receiving or not receiving radiation therapy postoperatively. The primary endpoint was local recurrence difference between the two groups.

Results: Local recurrence did not differ significantly between the two groups in terms of radiotherapy or not [odds ratio (OR) 0.96, 95% confidence interval (CI) 0.89-1.02, Fisher's exact test p = 0.388], nor between two age groups with cut-off at 65 years of age (OR: 0.99, 95% CI 0.92-1.07, Fisher's Exact test p = 0.6). Local recurrence also did not differ when subgroups of age (60-65 years and >66 years) were considered. All patients received 5 years of hormonal therapy.

Conclusion: Omission of radiotherapy in selected patients is not inferior to radiotherapy after breast conserving surgery in terms of preventing local recurrence.

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