自身免疫性脑炎和副肿瘤性脑炎:重症监护室的诊断和管理难题。

IF 1.2 4区 医学 Q4 DEVELOPMENTAL BIOLOGY
Mihaela Livia Agapie, Florin Tudor Borjog, Clementina Oana Dumitraşcu, Rareş Prăjescu, Mihai Popescu, Carmen Orban
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引用次数: 0

摘要

自身免疫性脑炎(AIE)是一类相对较新的神经系统疾病,其发病率不断上升,对医疗系统产生了重大影响,而且入住重症监护室(ICU)的比例很高。这类疾病通常需要及时治疗,甚至在明确诊断之前。在重症监护室,患者会出现非特异性的 AIE 体征和症状,这给治疗和诊断带来了挑战。患者经常表现出自主神经功能障碍、严重的躯体和精神躁动以及震颤和运动障碍,所有这些都使诊断变得更加复杂。他们容易发生感染,包括呼吸机相关肺炎,以及与静脉通路困难和压疮相关的问题。为了改善患者的预后,有必要尽早开始免疫抑制治疗。通过这篇文章,我们旨在总结目前在重症监护病房诊断和管理这种病症的困难方面的知识,以及在人力和财力资源方面对医疗系统的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Autoimmune encephalitis and paraneoplastic encephalitis: difficulties in diagnosis and management in the ICU.

Autoimmune encephalitis (AIE) represents a category of relatively newly described neurological disorders associated with an increasing prevalence, a significant impact on the healthcare system, and a high rate of intensive care unit (ICU) admission. This category of diseases often requires prompt treatment, even before a definitive diagnosis is established. In the ICU, patients present with nonspecific signs and symptoms for AIE, which pose challenges in both management and diagnosis. Patients frequently exhibit dysautonomia, severe physical and psychic agitation, as well as tremors and dyskinesia, all of which complicate the diagnosis. They are prone to developing infections, including ventilator-associated pneumonia, and issues related to difficult venous access and pressure ulcers. Early initiation of immunosuppressive treatment is necessary to improve patients' outcome. Through this article, we aimed to summarize current knowledge in terms of the difficulties in diagnosing and management of this pathology in the ICU, as well as the implications for the healthcare system in terms of human and financial resources.

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来源期刊
CiteScore
1.70
自引率
20.00%
发文量
221
审稿时长
3-8 weeks
期刊介绍: Romanian Journal of Morphology and Embryology (Rom J Morphol Embryol) publishes studies on all aspects of normal morphology and human comparative and experimental pathology. The Journal accepts only researches that utilize modern investigation methods (studies of anatomy, pathology, cytopathology, immunohistochemistry, histochemistry, immunology, morphometry, molecular and cellular biology, electronic microscopy, etc.).
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